| 马莹晔,曹熙,李慧,等.咽异感症与精神焦虑、抑郁的相关性研究及乌灵胶囊应用于咽异感症的疗效分析:一项随机、对照、开放研究[J].安徽医药,2020,24(9):1863-1867. |
| 咽异感症与精神焦虑、抑郁的相关性研究及乌灵胶囊应用于咽异感症的疗效分析:一项随机、对照、开放研究 |
| Correlation between pharyngeal paraesthesia and mental anxiety and depression and therapeutic effect of Wuling capsule on pharyngeal paraesthesia:a randomized，controlled，open study |
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| DOI：10.3969/j.issn.1009-6469.2020.09.043 |
| 中文关键词: 咽疾病 梅核气 咽异感症 焦虑 乌灵胶囊 抑郁 |
| 英文关键词: Pharyngeal diseases Globus hystericus Pharyngeal paraesthesia Anxiety Wuling capsule Depression |
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| 中文摘要: |
| 目的研讨咽异感症与精神焦虑、抑郁的相关性及乌灵胶囊应用于咽异感症的疗效。方法选取咽异感症病人 140例，每一例病人就诊时间范畴均处于 2017年 5月至 2018年 4月区间，就诊的医院均为蚌埠医学院第一附属医院耳鼻咽喉头颈外科门诊，使用 Excel生成随机数字表，划分为试验组和对照组，各 70例。针对每一例研究样本，均需要针对单例病人的个性化特征进行相关的资料采集。对照组给予巴特日七味丸，一日 2次，一次 10粒( 0.2克/粒)；试验组在对照组的基础上加用乌灵胶囊，一日 3次，一次 3粒( 0.33克/粒)。疗程为 2周。指导病人填写一般资料情况表、状态特质焦虑问卷(包含状态焦虑评分和特质焦虑评分)、医院焦虑抑郁量表［包含焦虑分量表( HAD-A)和抑郁分量表( HAD-D)］。治疗一月后请病人再次填写状态特质焦虑问卷、 HAD-D分量表，并结合病人主诉、咽喉局部体征等综合评价两组病人治疗疗效。结果排除剔除和脱落病例，最终完成本研究的病人为 132例，每组各 66例。咽异感症病人群体内中度焦虑以及中度抑郁者占比分别达到 52.27%、47.73%；相比于全国常模来说，此种病人所表现出的状态焦虑及特质焦虑评分水平明显升高( P＜0.001)。治疗一月后，两组病人的状态焦虑评分均较前降低( P＜0.05)；试验组 HAD-D评分较治疗前降低( P＜0.05)，对照组 HAD-D评分差异无统计学意义( P＞0.05)；试验组同对照组在状态焦虑评分方面的数据分别为( 39.47±5.68)分、(48.09±5.39)分，差异有统计学意义( P＜0.001)在 HAD-D评分方面，两组病人数据分别为( 6.78±2.93)分、(8.88±3.12)分，差异有统计学意义( P＜0.001)；两组病人的特质评分差异无统计学意义( P＞0.05)。试验组总有效率( 89.39%)较对照组( 62.12%)差异有统计学意义( P＜0.001)。结论焦虑是咽异感症的病因。乌灵胶囊能减轻病人焦虑抑郁情绪，有效提高咽异感症病人治疗疗效。 |
| 英文摘要: |
| Objective To investigate the correlation between pharyngeal paraesthesia and mental anxiety and depression and the clinical efficacy of Wuling capsule in the treatment of the disease.Methods A total of 140 patients with pharyngeal paraesthesiawho visited the Outpatient Department of Otorhinolaryngology Head and Neck Surgery，First Affiliated Hospital of Bengbu MedicalCollege between May 2017 to April 2018 were selected.And the hospitals visited are divided into experimental group and control group，with 70 cases in each group.For each study sample，relevant data collection is required for the individual characteristics of asingle patient.The control group was given Bate Riqiwei Pills，twice a day，10 pills at a time(0.2 g/capsule)and the experimental group was given Wuling capsule on the basis of the control group，3 times a day，3 pills at a time(0.33 g/capsule).The course of treatment was 2 weeks.The patients were instructed to fill in the general data questionnaire，the State-Trait Anxiety Inventory(in- cluding state anxiety score and trait anxiety score)，and the Hospital Anxiety and Depression Scale(including HAD-A and HAD-D subscales).After one month of treatment，the patients were asked to fill in the State-Trait Anxiety Inventory and the HAD-D sub- scale again，and comprehensively evaluate the therapeutic efficacy of the two groups of patients based on the patient’s main com- plaint and local throat signs.Results Excluding the cases of rejection and shedding，the number of patients who finally completed the study was 132，with 66 cases in each group.The proportions of patients with pharyngeal paraesthesia combined with moderateanxiety and moderate depression reached 52.27% and 47.73%，respectively.The state anxiety score and trait anxiety score of pa-tients with pharyngeal paraesthesia were significantly higher than those of the national norm(P＜0.001).After one month of treat- |
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