| 牛晓帅,肖武林,王艳.表柔比星 +奥沙利铂 +卡培他滨方案治疗晚期胃癌疗效与微小 RNA-196a表达的关系[J].安徽医药,2021,25(3):497-500. |
| 表柔比星 +奥沙利铂 +卡培他滨方案治疗晚期胃癌疗效与微小 RNA-196a表达的关系 |
| The relationship between the efficacy of EOX regimen in the treatment of advanced gastric cancer and the expression of miR-196a |
| |
| DOI：10.3969/j.issn.1009-6469.2021.03.016 |
| 中文关键词: 胃肿瘤 表柔比星 奥沙利铂 卡培他滨 抗肿瘤联合化疗方案 微小 RNA-196a 疗效 |
| 英文关键词: Stomach neoplasms Epirubicin Oxaliplatin Capecitabine Antineoplastic combined chemotherapy proto? cols MicroRNA-196a Therapeutic effect |
| 基金项目: |
|
| 摘要点击次数: 1434 |
| 全文下载次数: 572 |
| 中文摘要: |
| 目的探讨 EOX方案(表柔比星 +奥沙利铂 +卡培他滨)治疗晚期胃癌的疗效与血清微小 RNA-196a(microRNA-196a， miR-196a)表达的关系。方法选取 2014年 3月至 2015年 1月南阳油田总医院实施 EOX方案化疗的 96例晚期胃癌病人，所有病人均接受 4~6个周期化疗，依据实体瘤疗效评价标准( RECIST)评价标准将病人分为有效组 43例、无效组 53例，对比两组化疗前后的血清 miR-196a表达水平，采用 logistic回归分析法探讨血清 miR-196a表达水平对化疗效果的影响。结果经过化疗，有效组完全缓解( CR)2例、部分缓解( PR)41例，无效组疾病稳定( SD)47例、疾病进展( PD)6例；有效组病人的 miR-196a治疗前后差值( 2.87±0.77)显著高于无效组( 2.10±0.65)(P<0.05)；有效组和无效组病人的 TNM分期、肿瘤分化程度比较，差异有统计学意义( P<0.05)； logistic回归分析结果显示， TNM分期增高、分化程度低、化疗前 miR-196a高表达水平是晚期胃癌病人 EOX方案化疗效果不佳的独立危险性因素(P<0.05)。结论对于晚期胃癌病人，血清 miR-196a在经 EOX方案化疗后会显著降低，并且与病人化疗效果具有一定的相关性。 |
| 英文摘要: |
| Objective To explore the relationship between the efficacy of EOX regimen (epirubicin + oxaliplatin + capecitabine) inthe treatment of advanced gastric cancer and the expression of serum microRNA-196a (microRNA-196a, miR-196a).Methods A total of 96 patients with advanced gastric cancer who received EOX chemotherapy from Nanyang Oilfield General Hospital from March 2014to January 2015 were selected. All patients received 4 to 6 cycles of chemotherapy. According to the Response Evaluation Criteria inSolid Tumors (RECIST) evaluation criteria, patients were divided into effective group with 43 cases and ineffective group with 53 cases.The serum miR-196a expression levels of the two groups before and after chemotherapy were compared by logistic regression analysis.To explore the effect of serum miR-196a expression level on the effect of chemotherapy.Results After chemotherapy, 2 cases of com?plete relief (CR) in the effective group, 41 cases of partial remission (PR) in the effective group, 47 cases of stable disease (SD) in the in?effective group, 6 cases of disease progression (PD) in the ineffective group ; The difference between miR-196a before and after treat? ment in the effective group (2.87±0.77) was significantly higher than that of the ineffective group (2.10±0.65) (P<0.05); The comparisonof TNM staging and tumor differentiation between the effective group and the ineffective group was statistically significant (P<0.05); lo?gistic regression analysis showed that the TNM staging increased, the low degree of differentiation, and the high expression level of miR196a before chemotherapy was advanced The independent risk factors for the poor effect of EOX chemotherapy in patients with gastriccancer (P<0.05).Conclusion For patients with advanced gastric cancer, serum miR-196a will be significantly reduced after EOX regi?men chemotherapy, and has a certain correlation with the patient′s chemotherapy effect. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
