| 郑苗苗,唐昊.cGAS-STING通路通过调节巨噬细胞参与骨折愈合的研究进展[J].安徽医药,待发表. |
| cGAS-STING通路通过调节巨噬细胞参与骨折愈合的研究进展 |
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| 投稿时间：2023-10-18 录用日期：2023-11-06 |
| DOI： |
| 中文关键词: 骨折愈合 cGAS-STING通路 巨噬细胞 破骨细胞 |
| 英文关键词: |
| 基金项目:胞外囊泡来源miR-143介导的血管内皮细胞-成骨谱系细胞间通讯机制及其在骨组织再生微环境中的作用(82172431) |
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| 中文摘要: |
| 骨折愈合是一个复杂缓慢的动态过程，巨噬细胞是最早到达骨折部位的细胞之一。长期以来人们一直认为巨噬细胞有助于损伤部位的初始炎症和清创，它们在正常骨稳态和骨折愈合过程中调节骨再生中的关键作用也越来越受到重视。近年来，研究发现cGAS-STING通路是先天免疫和病毒防御中重要的 DNA传感机制，越来越多证据表明cGAS-STING通路与巨噬细胞密切相关,所以cGAS-STING通路可能通过调节巨噬细胞极化类型来作用骨折愈合。因此了解骨折修复过程中cGAS-STING通路参与调节巨噬细胞的机制，将为促进骨折修复提供新的思路和策略。 |
| 英文摘要: |
| Fracture healing is a complex and slow dynamic process, and macrophages are one of the first cells to arrive at the fracture site. It has long been thought that macrophages contribute to the initial inflammation and debridement at the site of injury, and the key role of macrophages in regulating bone regeneration during normal bone homeostasis and fracture healing is also receiving increasing attention. In recent years, studies have found that the cGAS-STING pathway is an important DNA sensing mechanism in innate immunity and virus defense, and more and more evidence shows that the cGAS-STING pathway is closely related to macrophages, so the cGAS-STING pathway may function in fracture healing by regulating the polarization type of macrophages. Therefore, understanding the mechanism of cGAS-STING pathway involved in the regulation of macrophages in the process of fracture repair, which will provide new ideas and strategies for promoting fracture healing. |
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