文章摘要
康茜,马凯.13号染色体缺失在多发性骨髓瘤的研究进展[J].安徽医药,待发表.
13号染色体缺失在多发性骨髓瘤的研究进展
投稿时间:2024-04-26  录用日期:2024-05-31
DOI:
中文关键词: 多发性骨髓瘤  13号染色体  预后  发病机制  
英文关键词: 
基金项目:
作者单位邮编
康茜 长治医学院 046000
马凯* 晋城市人民医院 
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中文摘要:
      多发性骨髓瘤(Multiple Myeloma, MM)作为一种由单克隆浆细胞恶性增生引起的血液系统肿瘤,在血液恶性肿瘤中位居第二,多见于老年人群,至今缺乏根治性治疗方案。尽管MM的具体发病机制尚未得到全面阐释,但累积的研究数据显示,染色体异常在MM发病中扮演了核心角色,涉及染色体结构和数目的多样变异,这些遗传学的异质性与MM的生物学特性密切相关。特别是13号染色体的缺失(The deletion of chromosome 13,del(13)),主要表现为13q14区域的缺失。这种缺失不仅是MM中一种常见的早期遗传学异常,而且伴随疾病的整个进展过程。因此,本综述旨在探讨13号染色体上相关基因在MM发病机制中的作用,旨在为理解MM的复杂病理生物学特性、指导临床治疗决策以及未来研究方向提供重要的参考信息。
英文摘要:
      Multiple Myeloma (MM), a hematologic tumor stemming from the malignant proliferation of monoclonal plasma cells, is the second most prevalent type of blood cancer, most commonly affecting the elderly. There are currently no definitive treatment options available for MM. Although the detailed pathogenic mechanisms of MM remain not fully elucidated, accumulated research has indicated that chromosomal abnormalities play a pivotal role in the disease"s onset, involving diverse variations in chromosomal structure and number. These genetic heterogeneities are closely linked to the biological characteristics of MM. Particularly, the deletion of chromosome 13, primarily manifesting as a loss in the 13q14 region, is not only a common early genetic abnormality in MM but also persists throughout the disease progression. Hence, this review aims to explore the role of genes on chromosome 13 in the pathogenesis of MM, providing crucial information for understanding the complex pathobiology of MM, guiding clinical treatment decisions, and shaping future research directions.
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