| 张泽.雄激素及雄激素受体与膀胱癌和顺铂化疗耐药性的研究进展[J].安徽医药,待发表. |
| 雄激素及雄激素受体与膀胱癌和顺铂化疗耐药性的研究进展 |
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| 投稿时间：2024-04-28 录用日期：2024-05-29 |
| DOI： |
| 中文关键词: 膀胱癌 雄激素 雄激素受体 顺铂 耐药性 |
| 英文关键词: |
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| 中文摘要: |
| 膀胱癌在男女之间发病率不同，男性比女性发病率高，但女性患者的预后往往比男性更差。这种差别可能不能完全归因于吸烟习惯、职业因素及年龄变化等，雄激素也可能是原因之一。雄激素在男性前列腺癌和睾丸癌中的作用已得到了充分的证实。雄激素及其受体也存在于人的膀胱组织中，它在膀胱癌发生发展中的作用，以及对膀胱癌患者化疗药物耐药性产生的关系，却备受争议。本文旨在概述雄激素及其受体在膀胱癌发生发展中的作用机制，及其对膀胱癌患者术后顺铂化疗耐药性的影响，以便更好使用这些药物。 |
| 英文摘要: |
| Abstract: The incidence of bladder cancer varies between men and women, with men having a higher incidence than women, but female patients tend to have a worse prognosis than men. This difference may not be entirely attributable to smoking habits, occupational factors and changes in age; androgens may also play a role. The role of androgens in prostate and testicular cancer in men is well established. Androgens and their receptors are also present in human bladder tissue. However, the role of androgens in the development of bladder cancer and the relationship with chemotherapy resistance in bladder cancer patients remains controversial. The aim of this review is to summarize the mechanism of action of androgens and their receptors in bladder carcinogenesis and progression, as well as the effect on resistance to postoperative cisplatin chemotherapy in bladder cancer patients, in order to make better use of these drugs. |
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