文章摘要
刘米特,姚娓.原发性失眠症患者发病机制及血清相关标志物的研究进展[J].安徽医药,待发表.
原发性失眠症患者发病机制及血清相关标志物的研究进展
投稿时间:2024-05-04  录用日期:2024-05-31
DOI:
中文关键词: 原发性失眠  血清标志物  炎症因子  神经递质
英文关键词: 
基金项目:辽宁省自然科学基金面上项目(2022-MS-334)
作者单位地址
刘米特 大连医科大学 辽宁省大连市大连医科大学旅顺校区
姚娓* 大连医科大学附属第二医院 
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中文摘要:
      目的:原发性失眠是一种常见的睡眠障碍,其治愈困难,对患者的正常工作和生活产生了严重的影响。由于目前没有明确的量化指标来提示原发性失眠症,本文就原发性失眠患者血清中相关标志物的研究进展进行综述,同时对原发性失眠的机制进行讨论,为今后的临床应用和实验研究提供参考。结论:目前研究认为原发性失眠与炎症密切相关,包括炎症因子的分泌失调、炎症重要标志物的水平升高、核内转录因子的活性升高;同时此类失眠与相关神经递质的分泌和神经系统标志物不同程度的表达、下丘脑-垂体-肾上腺(HPA)轴过度活跃密切相关。
英文摘要:
      Objective: Primary insomnia is a common sleep disorder, which is difficult to cure and has a serious impact on patients' normal work and life. Since there is no clear quantitative index to indicate primary insomnia, this paper reviews the research progress of related markers in serum of patients with primary insomnia, and also discusses the mechanism of primary insomnia, which will provide reference for future clinical application and experimental research. Conclusion: Current research suggests that primary insomnia is closely related to inflammation, including dysregulation of the secretion of inflammatory factors, elevated levels of important markers of inflammation, and elevated activity of intranuclear transcription factors; At the same time, this type of insomnia is closely related to the secretion of related neurotransmitters, the expression of neurological markers to varying degrees, and the overactivity of the hypothalamic-pituitary-adrenal (HPA) axis.
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