| 刘阳,高世乐,胡宗涛.放射性心脏损伤机制及其防治的研究进展[J].安徽医药,2016,20(10):1813-1816. |
| 放射性心脏损伤机制及其防治的研究进展 |
| Research progress in mechanism and treatment ofradiation-induced heart disease |
| 投稿时间：2016-02-23 |
| DOI： |
| 中文关键词: 肿瘤 放射治疗 放射性心脏损伤 作用机制 预防治疗 |
| 英文关键词: Tumor Radiotherapy Radiation-induced heart disease Mechanism of action Preventive treatment |
| 基金项目:南京军区面上项目(15M5049) |
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| 中文摘要: |
| 放疗是胸部恶性肿瘤的主要治疗手段之一。乳腺癌、肺癌、食管癌、纵隔淋巴瘤、胸腺瘤等胸部恶性肿瘤接受放射治疗时,肿瘤组织在受到放射线照射的同时,纵隔处的心脏亦不可避免受到不同体积、不同剂量的照射,引起不同程度的放射性心脏损伤(RIHD)。放射性损伤严重地影响了患者的生存质量,重者死亡,抵消放疗带来的生存受益。若能及早发现及时治疗急性放射性心脏损伤,降低放射后并发症的发生,可大幅度提高患者生存质量。因此研究放射性心脏损伤的发生条件、发生机制、临床特点、影像学及实验室检查以及防治措施,具有重要的临床意义。 |
| 英文摘要: |
| Radiotherapy is one of the main treatments of thoracic malignant tumors,including those of breast,lung,esophageal,mediastinal lymphoma and thymoma.During the treatment,part of the heart in mediastinum will inevitably receive different volumes and doses of irradiation when tumor tissues were exposed to radiation,which caused various degrees of radiation-induced heart disease(RIHD).The patients may seriously suffer from the late effect of radiotherapy,even die,which offsets the survival benefit.Therefore,in order to raise the survival quality of patients,it’s significant to detect acute RIHD timely,treat it promptly and reduce the late effect of radiotherapy,and meanwhile to study the conditions,mechanism,clinical features,imaging,laboratory examinations and prevention. |
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