| 曹军,姜楠,龙再菊.腹腔镜与传统根治术治疗结肠癌的疗效对比及术后血自由基水平检测[J].安徽医药,2018,22(6):1071-1074. |
| 腹腔镜与传统根治术治疗结肠癌的疗效对比及术后血自由基水平检测 |
| The curative effect comparison of laparoscopic and traditional radical surgery for colon cancer and detection of serum free radicals after surgery |
| 投稿时间：2016-10-31 |
| DOI： |
| 中文关键词: 结肠肿瘤 腹腔镜检查 结肠切除术 超氧化物歧化酶 丙二醛 |
| 英文关键词: Colonic neoplasms Laparoscopy Colectomy Superoxide dismutase Malondialdehyde |
| 基金项目: |
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| 中文摘要: |
| 目的 研究腹腔镜与传统根治术治疗结肠癌的疗效对比及术后血自由基水平检测。 方法 选取2014年10月至2015年9月辽宁中医药大学附属第三医院收治的88例结肠癌患者,根据随机数字表法分为观察组和对照组,每组44例。对照组为传统根治术,观察组借助腹腔镜完成手术治疗。比较两组患者术前、术后5 h血自由基相关指标——血清丙二醛(MDA)和超氧化物歧化酶(SOD)水平变化,观察两组患者的术中、术后情况及并发症发生情况。 结果 术后5 h,观察组的SOD水平(102.55±11.77) nU·mL-1显著高于对照组(92.93±10.09) nU·mL-1(t=4.116,P<0.001),MDA水平(11.48±0.39) mmol·L-1明显低于对照组(14.63±0.93) mmol·L-1(t=20.719,P<0.001)。观察组的手术切口长度(6.47±0.41) cm少于对照组(13.31±1.38) cm(t=31.516,P<0.001)、术中出血量(152.02±11.86) mL少于对照组(203.66±17.56) mL(t=16.165,P<0.001),淋巴结清扫数量(13.39±1.39)枚多于对照组(10.48±0.95)枚(t=11.465,P<0.001),但手术时间(186.41±13.59) min长于对照组(164.50±12.48) min(t=7.877,P<0.001)。观察组的术后镇痛时间、术后肠功能恢复时间、肛门排气时间、术后吗啡用量、住院时间显著少于对照组,但住院费用明显多于对照组,均差异有统计学意义(P<0.001)。观察组的粘连性肠梗阻率及总的并发症发生率显著低于对照组(P<0.001)。 结论 在治疗结肠癌患者中,使用腹腔镜手术治疗,相对于传统根治术,更有利于患者血自由基水平的恢复,有着较小的切口长度和术中出血量,效果较为显著,并发症发生率低。 |
| 英文摘要: |
| Objective To study the curative effect comparison of laparoscopic and traditional radical surgery in the treatment of colon cancer and to detect postoperative serum free radicals. Methods Eighty-eight cases of patients with colon cancer were selected who were treated from October 2014 to September 2015 in The Third Affiliated Hospital of Liaoning University of Chinese Medicine and assigned into observation group and control group,44 cases in each group,According to the random number method.control group was treated with traditional radical surgery while observation group was treated with laparoscopic surgery.The levels of serum malondialdehyde (MDA) and superoxide dismutase (SOD) were measured before and 5 hours after operation.The intraoperative and postoperative conditions and complications were observed and compared between the two groups. Results At 5 h after surgery,the SOD level in the observation group (102.55±11.77) nU·mL-1 was significantly higher than that in the control group (92.93±10.09) nU·mL-1 (t=4.116, P<0.001),and the MDA level (11.48±0.39) mmol·L-1 was significantly lower than that in the control group (14.63±0.93) mmol·L-1 (t=20.719, P<0.001).The length of the surgical incision (6.47±0.41) cm in the observation group was less than the control group (13.31±1.38) cm (t=31.516,P<0.001).The intraoperative blood loss (152.02±11.86) mL was less than the control group (203.66±17.56) mL (t=16.165,P<0.001),lymph node dissection number (13.39±1.39) was more than control group (10.48±0.95) (t=11.465,P<0.001),but operation time (186.41±13.59) min was longer than control group (164.50±12.48) min (t=7.877,P<0.001).The postoperative analgesia time,postoperative recovery time of intestinal function,anus exhaust time,postoperative morphine consumption,and length of stay in the observation group were significantly less than those in the control group,but hospitalization costs were significantly higher than those in the control group,and the differences were statistically significant (P<0.001).The obstructive intestinal obstruction rate and the incidence of total complications in the observation group were significantly lower than those in the control group (P<0.001). Conclusions In the treatment of colon cancer patients,the use of laparoscopic surgery,compared with the traditional radical surgery,is more conducive to the recovery of blood free radicals in patients with a shorter incision length and less intraoperative blood loss,therefore,the effect is more significant,and the complication rate is lower. |
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