| 胡雅婷,汪亚军,杨阿莉.甲巯咪唑联合糖皮质激素对甲状腺功能亢进合并症患者的临床疗效及安全性观察[J].安徽医药,2018,22(10):1990-1992. |
| 甲巯咪唑联合糖皮质激素对甲状腺功能亢进合并症患者的临床疗效及安全性观察 |
| Clinical efficacy and safety of methimazole combined with glucocorticoids in the treatment of hyperthyroidism complications |
| 投稿时间：2017-02-24 |
| DOI： |
| 中文关键词: 甲状腺功能亢进症 甲巯咪唑 地塞米松 比索洛尔 三碘甲状腺原氨酸 甲状腺素 治疗结果 |
| 英文关键词: Hyperthyroidism Methimazole Dexamethasone Bisoprolol Triiodothyronine Thyroxine Treatment outcome |
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| 中文摘要: |
| 目的 研究甲巯咪唑联合地塞米松治疗甲状腺功能亢进合并症的临床疗效及安全性。 方法 选取2015年2月至2016年2月间,在咸阳市第一人民医院内分泌科接受治疗的甲状腺功能亢进合并症患者94例。根据简单随机数字表法分为观察组和对照组各47例。两组均给予常规的甲状腺功能亢进对症药物及护肝等治疗,其中对照组给予口服比索洛尔治疗,观察组则给予口服甲巯咪唑联合地塞米松治疗。分别对比两组临床疗效、治疗前后甲状腺素水平与肝功能变化、不良反应发生情况。 结果 观察组治疗总有效率为91.49%(43/47),显著高于对照组的72.34%(34/47),差异有统计学意义(P＜0.05)。治疗后观察组血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)水平均显著低于对照组,均差异有统计学意义(均P＜0.05)。治疗后观察组谷丙转氨酶(ALT)、谷草转氨酶(AST)水平均显著低于对照组,均差异有统计学意义(均P＜0.05)。治疗后两组头痛、头晕、白细胞减少以及皮疹发生率均差异无统计学意义(均P＞0.05)。 结论 甲巯咪唑联合地塞米松治疗甲状腺功能亢进合并症的临床疗效显著,可显著改善患者甲状腺素水平以及肝功能,具有较好的安全性。 |
| 英文摘要: |
| Objective To study the clinical efficacy and safety of methimazole combined with dexamethasone in the treatment of hyperthyroidism complications. Methods Ninety-four patients with hyperthyroidism complications treated in the Department of Endocrine,the First People′s Hospital of Xianyang City from February 2015 to February 2016 were selected and assigned into two groups according to the simple random number method,each with 47 cases.The two groups were given conventional symptomatic hyperthyroidism drugs and other treatments such as liver protection. Based on this,the control group was additionally given the bisoprolol therapy,while the observation group was given methimazole with dexamethasone therapy.Then various indicators were compared between the two groups,including clinical curative effect,thyroid hormone levels and liver function changes,and adverse reactions.Results The total effective rate of the observation group was significantly higher than that of the control group [91.49% (43/47) vs. 72.34% (34/47)];the difference was statistically significant (P<0.05).FT3,FT4 levels of the observation group after treatment were significantly lower than those in the control group (all P<0.05).ALT,AST levels of the observation group after treatment were significantly lower than those in the control group (all P<0.05).After treatment,the incidences of headache,dizziness,leukopenia and rash contrast of both groups were not significantly different between the two groups (P>0.05). Conclusions The application of methimazole combined with dexamethasone is an effective and safe way to ameliorate the thyroid hormone levels and liver function for patients with hyperthyroidism complications. |
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