| 钟绍金,韩珊颖,明良山.高剪切条件下四臣止咳颗粒制备过程中润湿剂的动态分布[J].安徽医药,2018,22(12):2331-2334. |
| 高剪切条件下四臣止咳颗粒制备过程中润湿剂的动态分布 |
| Dynamic distribution of moistening agent in preparation of Sichen Zhike Granules by high shear wet granulation |
| 投稿时间：2017-03-03 |
| DOI： |
| 中文关键词: 湿法制粒 润湿剂分布 润湿性 荧光素钠 粒径分布 四臣止咳颗粒 |
| 英文关键词: Wet granulation Moistening agent distribution Wettability Sodium fluorescein Size distribution Sichen Zhike Granules |
| 基金项目: |
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| 中文摘要: |
| 目的 研究高剪切条件下制备四臣止咳颗粒过程中润湿剂的动态分布。 方法 以四臣止咳方浸膏粉-可溶性淀粉质量比为1∶2制备混合粉体,将示踪剂荧光素钠加入80%乙醇中作为润湿剂,高速搅拌湿法制粒；检测制粒过程不同时间点、不同粒径颗粒中荧光素钠的量,分析颗粒中润湿剂分布情况。 结果 在制粒初期颗粒粒径出现两极分化,且出现少量团块,主要在大粒径颗粒中检出荧光素钠,而小粒径颗粒中几乎检测不出荧光素钠,说明润湿剂此时主要呈现局部分布的状态；而随着制粒时间推移,颗粒粒径差别逐步缩小,荧光素钠在各粒径颗粒中分布趋向均衡,说明润湿剂此时趋向均匀分布的状态。 结论 高速搅拌湿法制备四臣止咳颗粒过程中,润湿剂分布随时间变化而趋向均匀化。 |
| 英文摘要: |
| Objective To explore the dynamic distribution of moistening agent in preparation of Sichen Zhike Granules during high shear wet granulation. Methods Sichen Zhike extract powder was utilized as a model drug and mixed with microcry stalline cellulose with the ratio of 1∶2 by weight.Fluorescein sodium was added to 80 % ethanol as wetting agent,using high speed wet granulation.The amount of fluorescein sodium of granulation process at different time points and different particle size,were detected to analyze the distribution of wetting agent.Results The moistening agent was heterogeneously distributed at the beginning of the process,and formed a small amount of clumps.Fluorescein sodium was detected in large particle size,while undetected ein small particles.It shows that wetting agent is mainly distributed in the state.With the passage of time,the difference of particle size gradually reduced,the distribution of sodium fluorescein in each particle size tends to be balanced,which shows that wetting agents present a uniform distribution.Conclusions In the process of wet granulation for preparation of Sichen Zhike Granules with highspeed stirring wet,wetting agent distribution tends to homogenization with time. |
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