| 李梅.血清胱抑素C和中性粒细胞明胶酶相关脂质运载蛋白检测对新生儿窒息后早期肾损伤诊断的价值[J].安徽医药,2019,23(7):1390-1392. |
| 血清胱抑素C和中性粒细胞明胶酶相关脂质运载蛋白检测对新生儿窒息后早期肾损伤诊断的价值 |
| CYS-C and NGAL combine detection the early diagnosis of renal damage in neonatal asphyxia |
| 投稿时间：2018-02-06 |
| DOI： |
| 中文关键词: 胱抑素C 中性粒细胞明胶酶相关脂质运载蛋白 新生儿窒息 肾损伤 |
| 英文关键词: Cystatin C NGAL Neonatal asphyxia Renal damage |
| 基金项目: |
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| 中文摘要: |
| 目的 血清胱抑素C(CYS-C)和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)联合检测在诊断新生儿窒息后早期肾损伤的应用。方法 选取2015年6月至2017年6月在宿州市立医院治疗的窒息足月新生儿45例,轻度窒息组25例,重度窒息组20例,另选取同时期出生40例足月健康的新生儿为对照组。分别检测尿素氮(BUN)、肌酐(SCr)、CYS-C、NGAL,并进行比较,并分析其受试者工作特征(ROC)曲线。结果 重度窒息组与轻度窒息组血清CYS-C(1.79±0.31)、(1.23±0.35)mg/L及NGAL检测结果(189.19±50.27)、(107.34±20.47)ng/mL均高于对照组(0.85±0.20)mg/L、(84.83±15.89)ng/mL ,差异有统计学意义。血清CYS-C、NGAL和BUN及SCr检测结果的ROC曲线分析(AUC)分别为90.1%,90.0%,77.6%及66.1%。单项检测CYS-C阳性率69.0%,NGAL阳性率62.0%,两项联合检测阳性率87.0%。结论 检测血清CYS-C、NGAL可以作为新生儿窒息早期肾损害的诊断指标,两种检测方法联合检测检出率高于单项检测法,并能对及时对症治疗得到明显改善者提供循证依据。 |
| 英文摘要: |
| Objective The application of serum Cystatin C (CYS-C) and neutrophil gelatinase-associated lipocalin (NGAL) was used to diagnose early injury after neonatal asphyxia.Methods From June 2015 to June 2017,5 cases of full-term newborn treated with asphyxia,25 cases of mild asphyxia and 20 cases of severe asphyxia in our hospital were selected.At the same period,40 cases of full-term healthy newborns were select as control group.BUN,SCr,CYS-C and NGAL were compared respectively.The ROC curve was analyzed by SPSS 17.0 software.Results The blood CYS-C and NGAL test of the severe asphyxia group and mild asphyxia group were staticaly significantly higher than the healthy control group(1.79±0.31),(1.23±0.35)mg/L and(189.19±50.27),(107.34±20.47)ng/mL vs.(0.85±0.20)mg/L,(84.83±15.89)ng/mL .The ROC curve analysis(AUC) of serum,CYS-C,NGAL and BUN and SCr test results was 90.1%,90.0%,77.6%,66.1%.The positive rate of CYS-C was 69.0%,the positive rate of NGAL was 62.0%,two combine testing positive rate was 87.0%.Conclusion Detection of blood CYS-C,NGAL can be used as the diagnostic index for early renal damage in neonatal asphyxia,and the detection rate of the tow detection methods is higher than that of single detection method.It provides a reliable basis for the obvious improvement of treatment. |
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