| 杨宏飞,鄢高亮.冻干重组人脑利钠肽用于心肌梗死急诊介入术后的近期影响分析[J].安徽医药,2019,23(10):2066-2069. |
| 冻干重组人脑利钠肽用于心肌梗死急诊介入术后的近期影响分析 |
| Short?term effects of lyophilized recombinant human brain natriuretic peptide in the treatment of acute myocardial infarction after emergency intervention |
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| DOI：10.3969/j.issn.1009?6469.2019.10.041 |
| 中文关键词: 心肌梗死 冻干重组人脑利钠肽 急诊 介入术 心功能 不良事件 再住院 |
| 英文关键词: Myocardial infarction Lyophilized recombinant human BNP Emergency department Interventional surgery Cardiac function Adverse events Rehospitalization |
| 基金项目:国家自然科学基金(81600227) |
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| 中文摘要: |
| 目的探究冻干重组人脑利钠肽(新活素)应用于急性心肌梗死急诊介入术后治疗的近期影响。方法选取东南大学附属中大医院江北院区 2017年 1月至 2018年 1月收治的急性心肌梗死急诊介入手术后病人 94例，按随机数字表法分为两组，各 47例。对照组采用常规抗血小板、抗凝、 β受体阻滞剂等治疗，观察组在对照组基础上加用新活素治疗以 0.01 μg·kg-1·min-1持续静脉泵入 4d左右。对比两组治疗前后心功能变化及不良事件发生率、再住院率。结果观察组术后 1周、 1个月氨基末端脑钠尿肽( NT?proBNP)、左房容积指数( LAVI)均低于对照组，左室射血分数( LVEF)高于对照组，差异有统计学意义( P＜0.05)；观察组不良事件发生率 8.51%(4/47)低于对照组 27.66%(13/47)差异有统计学意义( χ2＝5.817，P＝0.016)；观察组再住院率 2.13%(1/47)低于对照组 19.15%(9/47)，差异有统计学意义( χ2＝72，P＝0.007)。结论新活素应用于急性心肌梗死急.16，诊介入术后治疗可有效改善病人心功能，降低不良事件发生率及再住院率，值得临床推广。 |
| 英文摘要: |
| Objective To investigate the short?term effects of lyophilized recombinant human brain natriuretic peptide(BNP)in the treatment of acute myocardial infarction after emergency intervention.Methods Ninety?four patients with acute myocardial in?farction undergoing emergency interventional surgery in Zhongda Hospital Southeast University(Jiangbei)from January 2017 to Jan?uary 2018 were enrolled in the study and were assigned into two groups according to the random number table，with 47 cases in each group.The control group was treated with conventional therapy，and the observation group was treated with lyophilized recombi?nant human BNP in addition to the conventional therapy.The changes of cardiac function，adverse event rate and rehospitalization rate before and after treatment were compared between the two groups.Results The N?terminal pro?brain natriuretic peptide(NT?proBNP)and left atrial volume index(LAVI)were lower in the observation group than in the control group at 1 week and 1month after operation.The left ventricular ejection fraction(LVEF)in the observation group was significantly higher than that in the control group(P＜0.05).The incidence of adverse events(8.51%，4/47)in the observation group was lower than that(27.66%， 13/47)in the control group.The difference was statistically significant(χ2＝5.817，P＝0.016).The rehospitalization rate(2.13%，1/47) of the observation group was lower than that(27.66%，13/47)of the control group，and the difference was statistically significant(χ2＝7.162，P＝0.007).Conclusion The application of lyophilized recombinant human BNP to acute myocardial infarction afteremergency intervention can effectively improve the cardiac function，reduce the incidence of adverse events and the rate of rehospi? talization，which is worthy of clinical promotion. |
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