文章摘要
付长红,陆晓媛.斯钙素?2在子宫内膜癌中的表达[J].安徽医药,2020,24(1):144-146.
斯钙素?2在子宫内膜癌中的表达
Expression of calcitonin?2 in endometrial carcinoma
  
DOI:10.3969/j.issn.1009?6469.2020.01.036
中文关键词: 子宫内膜肿瘤  淋巴转移  肿瘤侵润  因果律  斯钙素 ?2
英文关键词: Endometrial neoplasms  Lymphatic metastasis  Neoplasm invasiveness  Causality  Stanniocalcin?2
基金项目:
作者单位E-mail
付长红 徐州医科大学附属医院妇产科江苏徐州221001
枣庄市立医院妇科山东枣庄 277101 
 
陆晓媛 徐州医科大学附属医院妇产科江苏徐州221001 fch2171@126.com 
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中文摘要:
      目的探讨斯钙素 ?2(stanniocalcin2,STC2)在子宫内膜癌中的表达以及与临床诊断中病理因素的相关性。方法对 50例子宫内膜癌病人利用半定量 RT?PCR检测和蛋白质印迹法法检测 STC2mRNA和 STC2蛋白在子宫内膜癌中表达的情况,分析 STC2表达与子宫内膜癌病人在临床诊断中病理因素的相关性。结果在 50例子宫内膜癌肿瘤组织中, STC2mRNA相对表达值为 2.45±0.27,显著高于癌旁组织 1.19±0.13(t=28.5,P=0.0034)STC2蛋白相对表达为 1.33±0.27,显著高于癌旁组织 0.28±0.05(t=26.4,P=0.0266); STC2的表达与病人的年龄与病理类型无明显关联( χ2=0.028,P=0.743)而与 FIGO分期( χ2=10.118,P=0.036)、腺癌病理分化程度( χ2=11.184,P=0.033)及淋巴结转移( χ2=14.322,P=0.012)相关结论 STC2 mRNA和 STC2蛋白在子宫内膜癌肿瘤组织中的表达显著高于癌旁组织; STC2表达与子宫内膜癌远处转移相关。
英文摘要:
      Objective To discuss the expression of STC2 in endometrial carcinoma and the relationship with pathology factors in diagnosis.Methods Fifty patients with endometrial carcinoma were chosen to detect the expression of STC2 mRNA and protein bysemi?quantitative RT?PCR and Western blot.Relationship with pathology factors was analyzed.Results In 50 cases of endometrial cancer,the relative expression of STC2 mRNA was 2.45±0.27,which was significantly higher than that of adjacent tissues 1.19±0.13(t=28.5,P=0.0034).The relative expression of STC2 protein was 1.33±0.27,which was significantly higher than that of adjacent tissues(0.28±0.05)( t=26.4,P=0.0266).STC2 expression was not significantly related to age and pathological classification(χ2= 0.028,P=0.743),but was significantly related to FIGO staging(χ2=10.118,P=0.036),pathological differentiation degree(χ2=11.184,P=0.033)and lymph node metastasis(χ2=14.322,P=0.012).Conclusion Expressions of STC2 mRNA and protein inendometrial carcinoma tumor tissues are significantly higher than those of para?carcinoma tissue.Expression of STC2 is relevant todistant metastasis of endometrial carcinoma.
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