| 于盼盼,杨忠杰,郭丽娜,等.基于网络药理学苍耳子的物质基础和作用机制的分析[J].安徽医药,2020,24(2):234-237. |
| 基于网络药理学苍耳子的物质基础和作用机制的分析 |
| Analysis of the material basis and mechanism of Xanthii Fructus based on network pharmacology |
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| DOI：10.3969/j.issn.1009?6469.2020.02.006 |
| 中文关键词: 苍耳子 数据库，事实型 化学，药物 谷甾醇 芦荟大黄素 磷脂酰肌醇 3?激酶 网络药理学 作用机制 肿瘤 神经系统 |
| 英文关键词: Fructus xanthii Databases,Factual Chemistry,Pharmaceutical Sitosterols Aloe?emodin Phosphatidylino? sitol?4,5?bisphosphate 3?kinase Network pharmacology Mechanism of action Tumor Nervous system |
| 基金项目:河南省教育厅科学技术研究重点项目( 15A360012)；河南省工程研究中心项目(豫发改高技〔2019〕569号)；漯河市工程技术研究中心项目(漯科〔2018〕88号)；漯河市创新型科技团队项目(漯科〔2018〕88号) |
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| 中文摘要: |
| 目的采用网络药理学方法探讨苍耳子功效的物质基础和作用机制。方法通过数据库( TCMSP)收集苍耳子的主要化学成分并筛选候选化合物，寻找其对应的靶点。通过 UniProt数据库提取作用靶点的基因名称，在 DAVID数据库获得与靶点相关的信号通路并进行富集筛选，采用 Cytoscape 3.7.0建立、网络图并通过 Omicshare 3.0对富 |
| 英文摘要: |
| Objective To explore the material basis and mechanism of the efficacy of Xanthii Fructus by network pharmacology. Methods The main chemical constituents of Xanthii Fructus were collected by database(TCMSP) and candidate compoundswere screened to find their corresponding targets.The gene name of the target was extracted by UniProt database，the target?relatedsignal pathway was obtained in DAVID database and enriched and screened.Cytoscape 3.7.0 was used to establish the "component?target" and "component?target?path" network maps.The enriched path is visualized by Omicshare 3.0，and finally the network dia? gram is analyzed using Network Analyzer under Cytoscape 3.7.0.Results A total of 9 major active components such as β?sitoster? ol，aloe?emodin and day lignan A were obtained，and 53 related targets were obtained.The main targets were PIK3CG，RELA，TP53， PRKCA，CASP3，etc.It integrates 37 pathways，including nervous system，anti?inflammatory，alcoholic fatty liver，immune system and anti?tumor pathways，which are mainly related to tumors and nervous system.Conclusion The main active components and poten?tial targets of Xanthii Fructus were discovered in this study.It is predicted to have certain effects in the treatment of tumor and ner?vous system related diseases，and provide reference for further study of its mechanism. |
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