| 王艳,郑夏生,李文康,等.黄芪破壁饮片 4种黄酮类成分分析及重金属含量测定[J].安徽医药,2020,24(2):247-251. |
| 黄芪破壁饮片 4种黄酮类成分分析及重金属含量测定 |
| Analysis of four flavonoids and determination of heavy metal content in ultrafine granular power of Radix Astragali |
| |
| DOI：10.3969/j.issn.1009?6469.2020.02.009 |
| 中文关键词: 黄芪 黄酮类 饮片 色谱法，高压液相 重金属残留 |
| 英文关键词: Astragalus membranaceus Flavones Herbal pieces for decoction Chromatography,high pressure liquid Heavy metal residuals |
| 基金项目:广东省科学技术厅科技计划项目( 2014B010108013) |
|
| 摘要点击次数: 2255 |
| 全文下载次数: 628 |
| 中文摘要: |
| 目的评价黄芪破壁饮片的有效性和安全性。方法利用高效液相色谱法建立一种可以同时测定黄芪破壁饮片中 4种黄酮类成分(毛蕊异黄酮葡萄糖苷、刺芒柄花苷、毛蕊异黄酮、芒柄花素)含量的方法，同时采用电感耦合等离子体质谱法对黄芪破壁饮片中 5种重金属( Cd、Cu、Pb、Hg、As)的含量进行监测。结果黄芪破壁饮片中 4种黄酮类成分的线性关系良好( r≥ 0.999 5)，加样回收率在 98.6 %~106.3 %之间，方法的重复性和稳定性良好，表明该方法可用于黄芪破壁饮片的 4种黄酮类成分含量的同时监测，可为黄芪质量控制提供更全面的参考； 10批黄芪破壁饮片中 5种重金属［镉( Cd)、铜( Cu)、铅( Pb)、汞(Hg)、砷( As)］的含量均符合相关限量规定。结论同时进行 4种黄酮类成分分析及重金属含量测定，可以从有效物质基础和有害元素多个角度综合评价黄芪的质量和安全性。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of Ultrafine Granular Power of Radix Astragali.Methods This experi?ment set up a method which can simultaneously determinate the contents of four flavonoids(Calycosin?7?O?glucoside，Ononin，Caly?cosin and Formononetion)in Ultrafine Granular Power of Radix Astragali.At the same time，Inductively Coupled Plasma Mass Spec?trometry was used to examine the contents of five heavy metal residuals(Cd，Cu，Pb，Hg，and As).Results Under the experimental conditions of our study，the four flavonoids had good linear relationship(r≥0.999 5)，and the recovery rate of four components were within 98.6% and 106.3%.The repeatability and stability of the method was considerable as well.The results show that this method could be applied to the determination of four flavonoids in Ultrafine Granular Power of Radix Astragali simultaneously and could provide more comprehensive reference for quality control of Radix Astragali.Besides，The contents of five heavy metal residuals(Cd，Cu，Pb，Hg，As)in the ten batches of Radix Astragali were in compliance with relevant regulations.Conclusion The qualityand safety of Radix Astragali can be evaluated comprehensively from the multiple perspectives of effective material basis and harm?ful elements by combining the content of active ingredients with the safety indicators such as heavy metals. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
