| 张庆伟,董洪权,金文杰,等.羟考酮有效抑制妇科腔镜手术病人术后拔管时的呛咳反应[J].安徽医药,2021,25(1):136-139. |
| 羟考酮有效抑制妇科腔镜手术病人术后拔管时的呛咳反应 |
| Oxycodone can effectively inhibit the cough response of patient undergoing extubation after gynecological endoscopic surgery |
| |
| DOI：10.3969/j.issn.1009?6469.2021.034. |
| 中文关键词: 麻醉，静脉 羟考酮 麻醉，吸入 内窥镜检查 妇科外科手术 咳嗽 气管插管拔除 疼痛，手术后 |
| 英文关键词: Anesthesia,intravenous Oxycodone Anesthetics,inhalation Endoscopy Gynecologic surgical procedures Cough Airway extubation Pain,postoperative |
| 基金项目:国家自然科学基金青年科学基金项目(81701375) |
|
| 摘要点击次数: 1626 |
| 全文下载次数: 467 |
| 中文摘要: |
| 目的观察羟考酮能否有效抑制妇科腔镜手术病人全麻术后拔管时的呛咳反应。方法选择 2018年 7月至 2019年 8月在南京医科大学第一附属医院于气管插管全麻下行择期妇科腔镜手术的病人 120例， ASA分级 Ⅰ～Ⅱ级，年龄范围为 18～ 65岁，采用随机数字表法分为羟考酮组(0.1 mg/kg)和对照组(等量 0.9%氯化钠溶液)每组 60例。两组病人分别于手术结束前 10 min静脉注射羟考酮 0.1 mg/kg或等量 0.9%氯化钠溶液。记录两组病人入恢复室，时(T1)、拔管时(T2)以及拔管后 3 min(T3)的血流动力学变化、拔管时间、拔管期间咳嗽的发生例数和咳嗽严重程度；拔管期间气道不良反应例数以及拔管后 5 min和 30 min时的视觉模拟评分法(VAS)评分；记录术后需追加镇痛药、术后不良反应的例数及拔管后 30 min改良 Aldrete评分。结果羟考酮组与对照组相比，在 T1、T2、T3时间点血流动力学变化未见明显差异；拔管期间咳嗽的发生率及严重程度明显降低(咳嗽例数 31/46例；重度咳嗽 2/11例， P＜0.05)；拔管时间、拔管期间气道不良反应、拔管后药物副作用及拔管后 30 min改良 Aldrete评分未见明显差异；羟考酮组拔管后 5 min、30 min时 VAS评分均明显低于对照组［(2.1±1.2)比(4.2±1.3)分；(1.9±1.1)比(4.1±2.2)分， P＜0.05］且需追加镇痛药例数少于对照组(0例/7例， P＜0.05)。结论妇科腔镜手术结束前 10 min静脉注射羟考酮 0.1 mg/kg能明显减少拔管时的呛咳反应，减轻术后疼痛且不增加不良反应。 |
| 英文摘要: |
| Objective To observe whether oxycodone can effectively inhibit the cough response during extubation of patients un?dergoing gynecological laparoscopic surgery after general anesthesia.Methods A total of120 patients with ASA grade I～Ⅱ，aged 18～65 years，undergoing elective gynecological endoscopic surgery with general anesthesia in the First Affiliated Hospital Of NanjingMedical University from July 2018 to August 2019 were randomly divided into oxycodone group(0.1 mg/kg)and control group(sa? line equivalent)with 60 cases in each group.Oxycodone 0.1 mg/kg or saline was injected intravenously 10 minutes before the end ofoperation in both groups.The hemodynamic changes were recorded at the time of entering the recovery room(T1)，extubation(T2) and 3 minutes after extubation(T3).The time of extubation，the cases of cough during extubation，the severity of cough(mild 0～2 times，moderate 3～5 times，severe＞5 times)，the number of airway reactions adverse andadditional analgesics and adverse drug re? actions during extubation，the Visual Analogue Scale(VAS)at 5 minutes and 30 minutes after extubation and modified Aldrete eval? uation in 30 minutes after extubationwere compared between the two groups.Results There was no significant difference in hemody? namic changes at T1，T2 and T3compared with the control group.the incidence and severity of cough during extubation in oxycodone group were significantly lower(incidence31 vs. 46 cases；severity of cough2 vs. 11 cases，P＜0.05)； the extubation time and side ef? fects of drugs and modified Aldrete score in 30 minutes after extubation were not significantly different；VAS scores in oxycodone group at 5 minutes and 30 minutes after extubation were significantly lower than those in the control group(2.1±1.2 vs. 4.2±1.3；1.9±1.1 vs. 4.1±2.2，P＜0.05)，and the cases requiring additional analgesics was less than the control group(0 vs. 7cases，P＜0.05).Con? clusion Intravenous injection of oxycodone 0.1 mg/kg 10 minutes before the end of gynecological laparoscopic surgery can signifi?cantly reduce the cough response during extubation and relieve the pain after operation without increasing adverse reactions. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
