| 王学博,任红娟,李松,等.腹腔热灌注化疗联合肿瘤细胞减灭术对卵巢癌病人血管内皮生长因子亚型及 T淋巴细胞亚群影响[J].安徽医药,2022,26(3):587-590. |
| 腹腔热灌注化疗联合肿瘤细胞减灭术对卵巢癌病人血管内皮生长因子亚型及 T淋巴细胞亚群影响 |
| Effect of intraperitoneal hyperthermic chemotherapy combined with tumor cell reduction on VEGF and T lymphocyte subsets in patients with ovarian cancer |
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| DOI：10.3969/j.issn.1009-6469.2022.03.039 |
| 中文关键词: 卵巢肿瘤 化学疗法，肿瘤，局部灌注 高温，诱发 腹腔热灌注化疗 细胞减灭术 血管内皮生长因子 T淋巴细胞亚群 |
| 英文关键词: Ovarian neoplasms Chemotherapy, cancer, regional perfusion Hyperthermia, induced Intraperitoneal hyperther mic chemotherapy Cytoreductive surgery Vascular endothelial growth factor T lymphocyte subsets |
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| 中文摘要: |
| 目的分析腹腔热灌注化疗联合肿瘤细胞减灭术对卵巢癌病人血清血管内皮生长因子( VEGF)亚型水平及静脉血 T淋巴细胞亚群影响。方法选取南阳市中心医院 2015年 8月至 2018年 6月收治的晚期卵巢癌病人 86例，按治疗方式分为对照组及观察组，各 43例。均行肿瘤细胞减灭术，对照组术后腹腔灌注化疗 1次联合静脉化疗 6周期，观察组术后腹腔热灌注化疗 3次，并联合静脉化疗 6周期，观察两组病人术中情况及术后恢复情况， 1年内复发及死亡情况、治疗前后血清 VEGF亚型水平及静脉血淋巴细胞亚群变化。结果观察组住院时间［(10.21±2.11)d］短于对照组［(13.79±2.57)d］(P<0.05)观察组 1年内复发率( 9.30%)低于对照组( 25.58%)(P<0.05)，观察组整体疗效明显优于对照组( P<0.05)总有效率( 69.77%)亦，明显高于对照组( 46.51%)(P<0.05)；治疗后观察组 VEGFA［(102.33±16.89)μg/L］、 VEGFB［(142.85±20.80)，μg/L］及 VEGFC［(91.33±20.64) μg/L］水平均低于对照组［( 186.36±21.55)μg/L、(291.22±23.05)μg/L、(189.96±24.78)μg/L］(P<0.001)；治疗后观察组 CD3+ |
| 英文摘要: |
| Objective To analyze the effect of intraperitoneal hyperthermic perfusion chemotherapy combined with tumor cell reduction on vascular endothelial growth factor (VEGF) subtypes in serum and T lymphocyte subsets in patients with ovarian cancer.Meth? ods Eighty-six patients with advanced ovarian cancer admitted to Nanyang Central Hospital from August 2015 to June 2018 were assigned into control group and observation group, 43 cases in each group. All patients were treated with cytoreductive surgery before patients in control group received intraperitoneal chemotherapy once combined with intravenous chemotherapy for six cycles and patientsin observation group received intraperitoneal hyperthermic chemotherapy three times combined with intravenous chemotherapy for sixcycles. The intraoperative condition and postoperative recovery of the two groups were observed. The recurrence and death within oneyear, the level of serum VEGF subtype and the changes of venous blood lymphocyte subsets before and after treatment were observed.Results The hospital stay in the observation group was shorter than that in the control group[(10.21±2.11) d vs. (13.79±2.57) d, P < 0.05], the recurrence rate in one year in the observation group was lower than that in the control group (9.30% vs. 25.58%, P < 0.05). The overall efficacy of the observation group was significantly better than that of the control group (P < 0.05), and the total effective rate was also significantly higher than that of the control group (69.77% vs. 46.51%, P < 0.05). After treatment the serum levels of VEGFA,VEGFB and VEGFC in the observation group [(102.33±16.89) μg/L, (142.85±20.80) μg/L,(91.33±20.64) μg/L] were lower than thosein the control group [(186.36±21.55) μg/L, (291.22±23.05) μg/L, (189.96±24.78) μg/L] (P < 0.001). The levels of CD3+, CD4+, CD4+/CD8+ in the observation group [(0.62±0.15), (0.51±0.15), (1.69±0.25)] were higher than those of the control group [(0.55±0.11), (0.41±0.13), (1.45±0.20)] (P < 0.05).Conclusion Intraperitoneal hyperthermic chemotherapy combined with cytoreductive surgery can inhibit the expression of VEGF in the serum of patients with ovarian cancer, improve the T lymphocyte immune function and reduce therecurrence of tumor. |
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