| 尹情胜,任翠丽,俞敏,等.溶解转移法测定盐酸多柔比星植入剂水分[J].安徽医药,2018,22(2):232-234. |
| 溶解转移法测定盐酸多柔比星植入剂水分 |
| Water determination in doxorubicin hydrochloride implants by dissolution and transfer method |
| 投稿时间：2017-01-05 |
| DOI： |
| 中文关键词: 盐酸多柔比星植入剂 水分测定 费休氏容量滴定法 溶解转移 费休氏试液标定 |
| 英文关键词: doxorubicin hydrochloride implants water determination volumetric fischer titration dissolution and transfer fischer reagent calibration |
| 基金项目: |
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| 摘要点击次数: 2301 |
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| 中文摘要: |
| 目的 建立费休氏容量滴定法测定盐酸多柔比星植入剂水分。 方法 用N,N-二甲基甲酰胺-甲醇混合溶剂溶解供试品制成溶液。用水-甲醇标准溶液标定费休氏试液后,先测定混合溶剂水分,再测定供试品溶液总水分,扣除混合溶剂水分后,得供试品水分。 结果 用混合溶剂溶解样品速度快,操作简单,可避免环境中水分的影响。费休氏试液标定偏差小,速度快。该方法重复性和日间精密度的RSD分别为1.24%(n=6)和1.32%(n=12),加标回收率在98%~102%之间,3批供试品水分在1.152%~1.233%范围内。 结论 费休氏容量滴定法可用于测定盐酸多柔比星植入剂水分。 |
| 英文摘要: |
| Objective To establish a volumetric Fischer titration method for determination of water in doxorubicin hydrochloride implants. Methods The implants were dissolved by N,N-dimethylformamide and methanol mixed solvents.Firstly,Fischer reagent was calibrated by water-methanol standard solution.Then water in the mixed solvent (W0) and water in the implants solution (W1) were determined respectively.Finally,water in the implants was got by W1 minus W0. Results The implants solution was prepared quickly and simply avoiding environmental water influence.Fischer reagent was titrated quickly and accurately.The RSDs of repeatability and interday precision were 1.24% (n=6) and 1.32% (n=12) respectively.The recoveries of water were 98%-102%. Conclusion This method is validated by methodology and suitable for determination water in the implants. |
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