| 袁舟亮,胡安群,刘海燕,等.血清中部分生化指标检测对恶性血液病诊断的意义[J].安徽医药,2019,23(2):304-306. |
| 血清中部分生化指标检测对恶性血液病诊断的意义 |
| Diagnostic significance of some serum biochemical indicators in patients with malignant hematonosis |
| 投稿时间：2017-02-26 |
| DOI： |
| 中文关键词: 血液病 β2-微球蛋白 乳酸脱氢酶 C-反应蛋白 铁蛋白 白蛋白 |
| 英文关键词: Hematonosis β2-microglobulin Lactatedehydrogenase C-reactive protein Ferritin Albumin |
| 基金项目: |
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| 摘要点击次数: 1832 |
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| 中文摘要: |
| 目的 探讨血清β2-微球蛋白(β2-MG)、乳酸脱氢酶(LDH)、C-反应蛋白(CRP)、铁蛋白(SF)、白蛋白(Alb)检测对良性血液病和恶性血液病诊断的意义。方法 选择2016年1—12月首次在安徽医科大学附属安庆医院住院的136例血液病病人,分为良性血液病和恶性血液病(MH)两组,良性血液病选择为缺铁性贫血者(IDA组)30例,MH组又分为淋巴细胞血液病者(LH组) 62例和非淋巴细胞血液病者(NLH组) 44例。另选取10例同期健康体检者为对照组。分析各组病人血清β2-MG、LDH、CRP、SF、Alb检测结果。结果 MH组、IDA组和对照组三组血清中β2-MG、LDH、CRP、Alb中位数差异有统计学意义(H=50.152、10.176、34.753、10.655,P<0.001、0.006、<0.001、0.005)。IDA组β2-MG、LDH、CRP中位数与对照组比较差异无统计学意义；MH组β2-MG、LDH、CRP中位数明显高于IDA组和对照组(t=7.476、3.784、5.563、8.223、4.025、5.530,均P<0.001)；IDA组和MH组Alb中位数比较差异无统计学意义,但均低于对照组,与对照组比较差异有统计学意义(t=4.295、6.078,均P<0.001),；IDA组男性病人和女性病人SF中位数都显著低于对照组(t=5.904、4.882,P=0.003、0.008),MH组男性病人和女性病人SF中位数都明显高于对照组(t=6.549、4.761,均P<0.001)；LH组β2-MG中位数高于NLH组(t=1 009.500,P=0.023),LH组Alb中位数低于NLH组(t=1 033.500,P=0.034),LDH、CRP、SF中位数比较差异无统计学意义。MH组中,β2-MG与CRP、LDH与CRP、LDH与SF、CRP与SF、β2-MG与Alb及CRP与Alb之间有相关性(rs=0.339、0.270、0.394、0.468、-0.549、-0.427,P<0.001、0.005、<0.001、<0.001、<0.001、<0.001),β2-MG与LDH、β2-MG与SF、LDH与Alb及Alb与SF之间无相关性。结论 血清β2-MG、LDH、CRP、SF、Alb水平在良性血液病和恶性血液病诊断、鉴别诊断中有重要临床意义。血液病病人进行实验室检查时,应全面检查,综合分析。 |
| 英文摘要: |
| Objective To discuss the diagnostic significance of serum levels of β2-microglobulin (β2-MG),lactatedehydrogenase (LDH),C-reactive protein (CRP),ferritin (SF),and Albumin (Alb) in patients with benignant hematonosis and malignant hematonosis.Methods A hundred and thirty-six cases of hematonosis hospitalized in Anqing Municipal Hospital for the first time from January 2016 to December 2016 were assigned into benignant hematonosis group and malignant hematonosis group (MH group).Thirty patients with iron deficiency anemia were in the benignant hematonosis group (IDA group),and MH group was composed of lymphocytic hematonosis subgroup (LH subgroup,62 cases) and nonlymphocytic hematonosis subgroup (NLH subgroup,44 cases).Meanwhile,another 10 healthy physical examinees were chosen for normal control group (control group).Analysis was made of the testing results of β2-MG,LDH,CRP,SF and Alb in serum of patients in each group.Results There were significant differences in the medians of β2-MG,LDH,CRP and Alb among MH group,IDA group and control group (H=50.152,10.176,34.753 and 10.655 respectively,P<0.001,0.006,<0.001 and 0.005 respectively).There were no significant differences in the medians of β2-MG,LDH,CRP between IDA group and control group.The medians of β2-MG,LDH,CRP in MH group were significantly higher than those in IDA group and control group (t=7.476,3.784,5.563,8.223,4.025 and 5.530 respectively,all P<0.001).The medians of Alb in IDA group and MH group had no statistically significant difference,but they were lower than that in control group with significant difference (t=4.295,6.078 respectively,both P<0.001).The medians of SF of both male and female patients in IDA group were significantly lower than that in control group (t=5.904,4.882 respectively,P=0.003,0.008 respectively),but the medians of SF of both male and female patients in MH group were significantly higher than that in control group (t=6.549,4.761 respectively,both P<0.001).The median of β2-MG in LH group was higher than that in NLH group (t=1 009.500,P=0.023).The median of Alb in LH group was lower than that in NLH group (t=1 033.500,P=0.034),but the median differences of LDH,CRP and SF between LH group and NLH group had no statistical significance.In MH group,there were correlations between β2-MG and CRP,LDH and CRP,LDH and SF,CRP and SF,β2-MG and Alb,and between CRP and Alb (rs=0.339,0.270,0.394,0.468,-0.549,-0.427 respectively,P<0.001,0.005,<0.001,<0.001,<0.001,<0.001 respectively),but there were no correlations between β2-MG and LDH,β2-MG and SF,LDH and Alb,and between Alb and SF.Conclusions The serum levels of β2-MG,LDH,CRP,SF and Alb have important clinical significance in the diagnosis and differential diagnosis of patients with benignant hematonosis and malignant hematonosis.The laboratory examination for patients with hematonosis need to be conducted and analyzed comprehensively. |
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