| 龚俊豪,汤慧敏,褚庆民,等.M1型巨噬细胞与不同类型冠心病的相关性研究[J].安徽医药,2020,24(5):899-902. |
| M1型巨噬细胞与不同类型冠心病的相关性研究 |
| The study of relationship between macrophage polarization M1 and different types of coronary heart disease |
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| DOI：10.3969/j.issn.1009?6469.2020.05.013 |
| 中文关键词: 冠心病 巨噬细胞 白细胞介素 1 CD86 |
| 英文关键词: Coronary disease Macrophages Interleukin?1 CD86 |
| 基金项目:广东省自然科学基金项目( 2017A030313745)；广东省医学科学技术研究基金项目( A2018222)；广东省中医药局项目(20181087) |
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| 中文摘要: |
| 目的探讨巨噬细胞极化 M1型与冠心病的相关性。方法选取 2018年 11月至 2019年 2月广州中医药大学第一附属医院住院的冠心病病人 120例(其中包括稳定型心绞痛组 40例，不稳定型心绞痛组 40例和急性心肌梗死组 40例)另外纳入同期排除冠心病 40例(对照组)测定各组冠心病与对照组巨噬细胞极化 M1型特异性标志物分化簇 86(CD86)和细胞，因子白细胞介素 1(IL?1)的表达情况，探讨，巨噬细胞极化 M1型与不同类型冠心病的相关性。结果外周血巨噬细胞的 CD86水平，对照组为( 36.314±17.08)ng/mL，冠心病组为( 133.945±117.78)ng/mL，稳定型心绞痛组为(40.850±8.18)ng/mL，不稳定型心绞痛组为(78.722±15.77)ng/mL，急性心肌梗死组为( 282.262±86.23)ng/mL，CD86水平冠心病组与对照组比较，差异有统计学意义( P＜0.001)，在冠心病组中，超敏肌钙 I和总胆固醇( TC)水平均与 CD86正相关。结论巨噬细胞极化 M1型与不同类型冠心病有显著相关性， M1型巨噬细胞水平或许可间接反映冠状动脉粥样硬化病变的严重程度。 |
| 英文摘要: |
| Objective To analyze the correlation between macrophage polarized M1 type and coronary heart disease. Methods 120 cases of patients with coronary heart disease in The First Clinical Medical College of Guangzhou University of Traditional Chi?nese Medicine from Nov.2018 to Feb.2019 were selected，including 40 patients with stable angina，40 patients with unstable angina， 40 patients with acute myocardial infarction and 40 patients with coronary heart disease.And the correlation between macrophage?polarized M1?type specific markers CD86 and cytokine IL?1，macrophage polarized M1 type and coronary heart disease were ana? lyzed.Results In this study，the average CD86 level of peripheral blood macrophages in the control group was(36.314±17.08)ng/ mL，the average CD86 level in the coronary heart disease group(133.945±117.78)ng/mL，the average CD86 level in the stable an? gina group was(40.850±8.18)ng/mL，and the average CD86 level in the unstable angina group was(78.722±15.77)ng/mL.The av? erage level of CD86 in the acute myocardial infarction group was(282.262±86.23)ng/mL，(P＜0.01，there was a statistical differ? ence in CD86 levels in the coronary heart disease group)，and the levels of hypersensitive intramuscular calcium I and TC in thecoronary heart disease group were statistically correlated with CD86.Conclusion There is a significant correlation between macro?phage polarization M1 and different types of coronary heart disease and the level of M1 macrophages may indirectly reflect the se?verity of coronary atherosclerotic lesions. |
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