| 王波,王妃,刘天媚.儿童功能性消化不良 140例临床分析[J].安徽医药,2020,24(10):2047-2049. |
| 儿童功能性消化不良 140例临床分析 |
| Clinical analysis of 140 children with functional dyspepsia |
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| DOI：10.3969/j.issn.1009?6469.2020.10.033 |
| 中文关键词: 消化不良/病因学 瘦素 胃促生长素 功能性消化不良 幽门螺旋杆菌 胃肠激素 儿童 |
| 英文关键词: Dyspepsia/ etiology Leptin Ghrelin Functional dyspepsia Helicobacter pylori Gut hormone Child |
| 基金项目: |
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| 摘要点击次数: 1469 |
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| 中文摘要: |
| 目的探讨琼海市儿童功能性消化不良(Functional Dyspepsia，FD)与胃肠激素之间的关系，为本市儿童 FD的防治提供科学依据。方法选取 2017年3月至 2019年3月在琼海市中医院就诊的 140例6～13岁儿童，年龄(9.1±2.3)岁，根据年龄将病儿分为≤9岁组和＞ 9岁组，其中男 86例，女54例，采用罗马 Ⅳ标准进行 FD诊断，比较两组病儿 FD的常见临床表现；幽门螺旋杆菌(He? licobacter Pylori，Hp)感染检查采用 13C呼气试验，采用 ELISA法检测病儿血浆中的瘦素、生长素及酪酪肽水平，并分析这三种胃肠激素与 FD病儿 Hp感染之间的关系；采用 SPSS 22.0统计软件进行分析。结果研究发现， 140例病儿中上腹痛的发生率最高(93.57%)其次为恶心和(或)呕吐(74.29%)、早饱(55%)和腹胀(31.43%)。≤9岁组与＞ 9岁组相比，腹痛、恶心和(或)呕吐差异无统计学(P＞0.05)；早饱、腹胀差异有统计学意义(P＜0.05)。不同组间儿童 Hp阳性率比较差异无统计学意义(P＞0.05)两组病儿血浆中瘦素水平比较， Hp阳性组病儿血浆中瘦素水平(2 435.32±256.13)ng/L显著高于 Hp阴性组(1 898.45±304.88)ng意义，/。L；两组病儿血浆中生长素水平比较， Hp阳性组病儿血浆中生长素水平(212.06±19.81)ng/L显著低于 Hp阴性组(296.27±26.57)ng/ L；两组病儿血浆中酪酪肽水平比较 Hp阳性组病儿血浆中酪酪肽水平与 Hp阴性组相比差异无统计学意义(P＞0.05)。结论瘦素、生长素及酪酪肽这三种胃肠激素参与了儿童 FD的发病机制，可能会成为儿童 FD临床治疗的新靶点。 |
| 英文摘要: |
| Objective To explore the relationship between functional dyspepsia(FD)and gastrointestinal hormones in children in Qionghai city，and to provide scientific evidence for prevention and treatment of FD in children in this city.Methods A total of 140 children aged 6?13 years old who were admitted to the Qionghai Hospital of Traditional Chinese Medicine from March 2017 toMarch 2019 were selected，with the age of(9.1±2.3)years old.The children were divided into ≤9 years old group and＞9 years old group according to age，including 86 males and 54 females.The FD diagnosis was performed using the Rome III criteria.Thecommon clinical manifestations of FD in the two groups were compared.The Helicobacter pylori(Hp)infection was tested by 13C breath test and detected by ELISA.The plasma levels of leptin，ghrelin and PYY were analyzed，and the relationship between thesethree gut hormones and Hp infection in children with FD was analyzed.SPSS 22.0 statistical software was used for analysis.Re? sults The study found that the incidence of upper abdominal pain was highest in 140 patients(93.57%)，followed by nausea and/ or vomiting(74.29%)，early satiety(55%)and bloating(31.43%).There was no significant difference in abdominal pain，nausea and/or vomiting between the 9?year?old group and the＞9?year?old group(P＞0.05).The difference of early satiety and abdominal distension was statistically significant(P＜0.05).There was no significant difference in Hp positive rate between children in differ? ent groups(P＞0.05).The plasma leptin level in HP positive group(2 435.32±256.13)ng/L was significantly higher than that in HP negative group(1 898.45±304.88)ng/L；ghrelin auxin level in HP positive group(212.06±19.81)ng/L was significantly lower than that in HP negative group(296.27±26.57)ng/L.There was no significant difference in the plasma PYY level between the twogroups in the Hp positive group and the Hp negative group(P＞0.05).Conclusion Leptin，ghrelin and PYY are involved in thepathogenesis of childhood FD and may become a new target for clinical treatment of children with FD. |
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