| 秦万,王琼,欧维正,等.微孔药敏检测法检测耐多药结核病 33例耐药分析[J].安徽医药,2022,26(1):91-93. |
| 微孔药敏检测法检测耐多药结核病 33例耐药分析 |
| Analysis of drug resistance in 33 cases of multidrug-resistant tuberculosis by microporous antimicrobial susceptibility testing |
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| DOI：10.3969/j.issn.1009-6469.2022.01.021 |
| 中文关键词: 广泛耐药结核 结核，抗多种药物性 耐多药结核病(MDR-TB) 微孔药敏检测法 耐药率 |
| 英文关键词: Extensively drug-resistant tuberculosis Tuberculosis, multidrug-resistant MDR-TB Microporous plate method Drug resistance rate |
| 基金项目:贵阳市科技计划项目(筑科合同〔2018〕1-41号) |
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| 中文摘要: |
| 目的探讨 MicroDSTTM(微孔药敏检测法)微孔板法检测结核分枝杆菌的耐药情况分析。方法用 MicroDSTTM微孔板法对贵阳市公共卫生救治中心 2018年 1月至 2019年 11月期间部分用比例法药敏试验随机筛选的 33例耐多药结核病(MDR-TB)阳性菌株进行 16种抗结核药药物敏感性检测。结果异烟肼、利福平耐药率与比例法比较符合率为 97.0%(32/33)、 93.9%(31/ 33)；对 16种药总耐药率 33%(174/528)；一线总耐药率 70.5(93/132)、二线总耐药率 20.5(81/396)。结论微孔板法检测的 MDR-TB病人筛选率与比例法具有较高符合率、且本地区 MDR-TB病人的耐药情况较严重，应加强药物监测，选择有效药物化疗，而 MicroDSTTM微孔板法的推广使用有利于 MDR-TB诊断和药物筛选。 |
| 英文摘要: |
| Objective To explore the analysis of drug resistance of Mycobacterium tuberculosis detected by MicroDSTTM (micropo-rous drug sensitivity test) microplate method.Methods A total of 33 multi-drug resistant tuberculosis (mDR-TB) positive strains ran-domly selected by proportional method in Guiyang Public Health Treatment Center from January 2018 to November 2019 were selectedfor drug susceptibility detection of 16 anti-tuberculosis drugs by MicroDSTTM microplate method.Results The drug resistance detec-tion rate of isoniazid and rifampicin were 97.0% (32/33) and 93.9% (31/33), respectively. The total drug resistance rate to 16 drugs was33% (174/528), the first-line total drug resistance rate was 70.5 (93/132) and the second-line total drug resistance rate was 20.5 (81/ 396).Conclusion The screening rate of MDR-TB patients detected by microplate method is in high accordance with the proportion method, and the drug resistance of MDR-TB patients in this area is serious, so it is necessary to strengthen drug monitoring and selecteffective drug chemotherapy, while the promotion and use of MicroDSTTM microplate method is conducive to MDR-TB diagnosis and drug screening. |
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