| 曹银,陈学萍,徐亚运,等.精神分裂症应用氯氮平228 例初期血药浓度与临检指标水平的相关性[J].安徽医药,2022,26(5):1048-1051. |
| 精神分裂症应用氯氮平228 例初期血药浓度与临检指标水平的相关性 |
| Correlation between initial blood concentration of clozapine and clinical indicators in 228 patients with schizophrenia |
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| DOI：10.3969/j.issn.1009-6469.2022.05.047 |
| 中文关键词: 精神分裂症 淋巴细胞百分比 中性粒细胞百分比 红细胞 血红蛋白 氯氮平 |
| 英文关键词: Schizophrenia Percentage of lymphocytes Percentage of neutrophils Red blood cells Hemoglobin Clozapine |
| 基金项目:合肥市第六周期医学重点学科特色专科经费资助项目 |
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| 中文摘要: |
| 目的研究精神分裂症病人使用氯氮平初期血药浓度与临检指标水平的相关性。方法收集2018年1月至2019年1月在安徽医科大学附属心理医院住院治疗的精神分裂症病人228例氯氮平血药浓度及其人口学资料和实验室临检指标。采用Pearson 相关检验和多元线性回归分析氯氮平血药浓度与实验室临检指标的关系。结果Pearson 相关分析结果表明，氯氮平血药浓度与中性粒细胞百分比(r =0.19，P = 0.005)呈正相关关系；而与淋巴细胞百分比(r=?0.14，P=0.038)、红细胞数目(r =?0.14，P=0.033)和血红蛋白浓度(r =?0.21，P = 0.001)呈负相关关系。此外，调整混杂因素后，多元线性回归分析结果显示，中性粒细胞百分比(Beta=0.468)对氯氮平血药浓度影响最大。结论精神分裂症病人血液中中性粒细胞百分比升高的病人应监测其氯氮平血药浓度。临检指标水平为精神分裂症病人氯氮平群体药动学参数的选择提供了一定的依据。 |
| 英文摘要: |
| Objective To study the correlation between initial blood concentration of clozapine and clinical indicators in patients with schizophrenia.Methods The clozapine plasma concentrations of 228 schizophrenia patients treated with clozapine and their de?mographic data and laboratory clinical indicators were collected in Affiliated Psychological Hospital of Anhui Medical University from January 2018 to January 2019. Relationships between the serum clozapine concentration with clinical indicators were analyzed by Pear?son correlation tests and multivariate linear regression analysis.Results Pearson correlation analysis showed that serum clozapine con?centrations were positively correlated with the percentage of neutrophils (r=0.19,P=0.005) and negatively correlated with the percentage of lymphocytes (r=?0.14,P=0.038), the number of red blood cells (r=?0.14,P=0.033), and the hemoglobin concentration (r=?0.21,P=0.001). In addition, after adjusting for confounding factors, the results of multiple linear regression analysis showed that the percentage of neutrophils (Beta=0.468) has a greatest effect on the blood concentration of clozapine.Conclusions Clozapine plasma concentration should be monitored in patients with schizophrenia who have an elevated percentage of neutrophils.The level of clinical indicators pro?vides a basis for the selection of pharmacokinetic parameters of clozapine in schizophrenia patients. |
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