| 付雪莲,臧密密,苗艳,等.信号转导和转录激活因子 3和长链非编码 RNA肿瘤易感候选基因 11在子痫前期胎盘中的表达及与胎盘螺旋动脉重铸的关系[J].安徽医药,2024,28(3):522-525. |
| 信号转导和转录激活因子 3和长链非编码 RNA肿瘤易感候选基因 11在子痫前期胎盘中的表达及与胎盘螺旋动脉重铸的关系 |
| Expression of STAT3 and lncRNA CASC11 in the placenta of preeclampsia and their relationship with placental spiral artery remodeling |
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| DOI：10.3969/j.issn.1009-6469.2024.03.020 |
| 中文关键词: 先兆子痫 胎盘螺旋动脉重铸 子痫前期 长链非编码 RNA肿瘤易感候选基因 11 信号转导及转录活化因子 3 妊娠高血压 |
| 英文关键词: Pre-eclampsia Placental spiral artery remodeling Preeclampsia Long non-coding RNA cancer susceptibility candi. date 11 Signal transducer and activator of transcription 3 Gestational hypertension |
| 基金项目:河北省卫健委医学科学研究计划项目( 20210598) |
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| 中文摘要: |
| 目的探究子痫前期( PE)病人胎盘组织中信号转导及转录活化因子 3(STAT3)、长链非编码 RNA肿瘤易感候选基因 11(lncRNA CASC11)表达水平与胎盘螺旋动脉重铸的关系。方法选取 2019年 1月至 2022年 4月于沧州市人民医院行剖宫产分娩的 68例 PE病人为 PE组，并选取同期该院行剖宫产分娩的 68例健康孕妇为健康组。比较 PE组、健康组一般资料及胎盘组织中 STAT3 mRNA、lncRNA CASC11表达水平；分析 PE病人胎盘组织中 STAT3 mRNA表达水平与 lncRNA CASC11的相关性；比较健康组与 PE组胎盘螺旋动脉管壁厚度、管腔面积；分析 PE病人胎盘组织中 STAT3 mRNA、lncRNA CASC11表达水平与胎盘螺旋动脉管壁厚度、管腔面积的相关性。结果 PE组病人舒张压、收缩压高于健康组( P<0.05)胎盘组织中 STAT3 mRNA、lncRNA CASC11表达水平分别为 0.40±0.14、0.46±0.15，低于健康组的 1.04±0.35、1.01±0.34(P<0.05)，，胎盘螺旋动脉管壁厚度高于健康组( P<0.05)，管腔面积小于健康组( P<0.05)； PE病人胎盘组织中 STAT3 mRNA表达水平与 lncRNA CASC11，及 STAT3 mRNA、lncRNA CASC11表达水平与胎盘螺旋动脉管腔面积均呈正相关( P<0.05)，STAT3 mRNA、lncRNA CASC11表达水平与胎盘螺旋动脉管壁厚度呈负相关( P<0.05)。结论 PE病人胎盘组织中 STAT3 mRNA、lncRNA CASC11表达水平均较低，二者均与胎盘螺旋动脉重铸关系密切，可能为临床诊治 PE提供新方向。 |
| 英文摘要: |
| Objective To investigate the relationship between the expression levels of signal transducer and activator of transcription 3 (STAT3) and long non-coding RNA tumor susceptibility candidate gene 11 (lncRNA CASC11) in placental tissue and placental spiralartery remodeling of patients with preeclampsia (PE).Methods A total of 68 PE patients who underwent cesarean delivery in Cang.zhou People's Hospital from January 2019 to April 2022 were selected as the PE group, and 68 healthy pregnant women who underwentcesarean delivery were taken as the healthy group. The general data and the expression levels of STAT3 mRNA and lncRNA CASC11in placental tissue of PE group and healthy group were compared; the correlation between STAT3 mRNA expression level and lncRNACASC11 in placental tissue of PE patients was analyzed; the wall thickness and lumen area of the placental spiral artery were comparedbetween the healthy group and the PE group; the correlation between the expression levels of STAT3 mRNA and lncRNA CASC11 inplacental tissue of PE patients and the wall thickness and lumen area of the placental spiral artery was analyzed.Results The diastolic blood pressure and systolic blood pressure of the PE group were higher than those of the healthy group (P<0.05), the expression levelsof STAT3 mRNA and lncRNA CASC11 in the placenta tissue were 0.40±0.14 and 0.46±0.15, respectively, which were lower than thoseof the healthy group (1.04±0.35, 1.01±0.34) (P<0.05), and the thickness of the placental spiral artery wall was higher than that of the healthy group (P<0.05), the lumen area was smaller than that of the healthy group (P<0.05); the expression level of STAT3 mRNA inplacental tissue of PE patients was positively correlated with lncRNA CASC11, and the expression levels of STAT3 mRNA and lncRNACASC11 were positively correlated with the lumen area of placental spiral artery (P<0.05), the expression levels of STAT3 mRNA and lncRNA CASC11 were negatively correlated with the thickness of the placental spiral artery wall (P<0.05).Conclusion The expres.sion levels of STAT3 mRNA and lncRNA CASC11 in the placental tissue of PE patients are lower, both are closely related to the pla.cental spiral artery remodeling, which may provide a new direction for clinical diagnosis and treatment of PE. |
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