| 汤洁.血浆基础N末端B型利钠肽原水平对高龄心力衰竭患者应用左西孟旦近期临床疗效的预测价值[J].安徽医药,2016,20(7):. |
| 血浆基础N末端B型利钠肽原水平对高龄心力衰竭患者应用左西孟旦近期临床疗效的预测价值 |
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| 投稿时间：2016-05-23 录用日期：2016-06-07 |
| DOI： |
| 中文关键词: N末端B型利钠肽原 左西孟旦 心力衰竭 预测价值 |
| 英文关键词: N-terminal-pro-brain natriuretic peptid levosimendan heart failure prognosis |
| 基金项目:无 |
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| 中文摘要: |
| 目的 评价基础血浆NT-proBNP水平对高龄心力衰竭患者应用左西孟旦近期临床疗效的预测价值。方法 采用前瞻性观察研究方法,28例高龄心功能分级为Ⅲ～Ⅳ级的心力衰竭患者纳入研究,在基础心衰治疗基础上加用左西孟旦,入选患者于入院时检测基础血浆NT-proBNP水平,依据其四分位数值作为界限,分为四组,并于入院24小时内及治疗后行心脏超声检查,测定左室射血分数(LVEF%),观察患者出院时心功能改善情况,计算LVEF%变化值。采用Pearson双变量相关分析评价血浆基础NT-proBNP水平与治疗前后患者LVEF%水平差值的相关性,应用双向有序分类资料线性趋势检验比较各组间整体临床状况改善程度。结果 基础血浆NT-proBNP值与左西孟旦用于心衰患者的心功能改善程度负相关,且呈线性变化趋势。心衰患者经治疗后LVEF%变化值与基础血浆NT-proBNP水平呈显著负性相关。结论 基础血浆NT-proBNP值可能成为评估预测高龄心衰患者应用左西孟旦临床疗效的手段之一。 |
| 英文摘要: |
| Objiective To investigate the predictive values of baseline plasma NT-proBNP levels for short-term clinical efficacy of levosimendan in patients with heart failure. Methods A prospective observational study was conducted,A total of 28 aged heart failure patients with NYHA class III to IV were collected.Appropriate conventional therapies for heart failure were given combined with levosimendan. Baseline plasma concentrations of NT-proBNP were measured immediately after admission, The patients were divided into four groups according to the quartile of NT-proBNP levels.And the echocardiography were performed to determinate of LVEF% before and after treatment. Difference in changes of NYHA class between the four groups and the relationship between baseline NT-proBNP and the numerical of LVEF% changed were analyzed. Results A negative correlation trend was found between NT-proBNP values and the degree of improvement in LVEF%(r=-0.455,p=0.022). The degree of improvement in overall clinical status was statistically significant among the four groups(p<0.05).Conclusion Baseline NT-proBNP is a effective predictor for evaluation of short-term clinical efficacy of levosimendan in patients with heart failure. |
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