| 查翔远,翟群超,吴建成,等.肝细胞癌组织中IL-18BPc和VEGF的表达及与肿瘤血管形成的关系[J].安徽医药,2016,20(1):82-85. |
| 肝细胞癌组织中IL-18BPc和VEGF的表达及与肿瘤血管形成的关系 |
| Expression of IL-18BPc and VEGF in hepatocellular carcinoma and its relationship with tumor angiogenesis |
| 投稿时间：2015-10-12 |
| DOI： |
| 中文关键词: 肝细胞癌 血管生成 白介素-18 结合蛋白 血管内皮生长因子 微血管密度 免疫组织化学 |
| 英文关键词: hepatocellular carcinoma angiogenesis interleukin-18 binding protein VEGF MVD immunohistochemistry |
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| 中文摘要: |
| 目的 探讨IL-18BPc和VEGF在原发性肝细胞癌组织中的表达及其与肿瘤血管形成之间的关系。方法 应用免疫组织化学SP法检测IL-18BPc和VEGF在34例肝细胞癌组织、34例癌旁肝组织及12例正常肝组织的表达,通过CD34免疫组织化学染色评价肿瘤组织MVD值,分析IL-18BPc表达与VEGF表达及MVD的关系。结果 IL-18BPc在肝癌组织中的表达阳性率高于癌旁肝组织(P＜0.01)及正常肝组织(P＜0.01),且肝癌出现侵袭转移者较未出现侵袭转移者其IL-18BPc表达阳性率高(P＜0.01)；VEGF在肝癌组织中的表达高于癌旁肝组织(P＜0.01)及正常肝组织(P＜0.01)；IL-18BPc和VEGF在肝细胞癌中表达呈正相关(r=0.357, P=0.037)；肝癌组织MVD值与高于癌旁肝组织(P＜0.01)及正常肝组织(P＜0.01)；肝癌组织中, IL-18BPc阳性表达者MVD值高于阴性表达者(P=0.004)。结论 IL-18BPc可能通过上调VEGF的表达促进肝细胞癌血管形成。 |
| 英文摘要: |
| Objective To detect IL-18BPc and VEGF expression in hepatocellular carcinoma (HCC) and to investigate the relationship of this expression with tumor angiogenesis.Methods IL-18BPc and vascular endothelial growth factor (VEGF) expressions in 34 specimens of HCC, 34 specimens of adjacent non-tumorous liver tissue, and 12 specimens of normal liver tissue were detected by immunohistochemistry. Microvessel density (MVD) was determined by labeling the vascular endothelial cells with cluster of differentiation 34(CD34). Correlation between the expression of IL-18BPc and VEGF in HCC tissue was analysed. Results The expression of IL-18BPc protein in HCC tissue was significantly higher than that in adjacent non-tumorous liver tissue(P＜0.01) and normal liver tissue(P＜0.01), moreover, this expression was related to tumor metastasis in HCC. The expressions of VEGF protein and CD34 in PHC tissue were significantly higher than those in adjacent non-tumorous liver tissue(P＜0.01) and normal liver tissue(P＜0.01). IL-18BPc expression in HCC tissue was positively correlated with VEGF expression(r=0.357, P=0.037). MVD of specimens with IL-18BPc positive expression was significantly higher than those with IL-18BPc negative expression in HCC tissue(P=0.004). Conclusions IL-18BPc possibly promotes tumor angiogenesis through upregulation of VEGF expression in HCC. |
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