| 刘俊丽,段松冷,曾蔚欣.氨薄荷搽剂中薄荷脑含量测定方法研究[J].安徽医药,2016,20(2):267-270. |
| 氨薄荷搽剂中薄荷脑含量测定方法研究 |
| Syudy on concentration determination of menthol in ammonia and menthol spiritus |
| 投稿时间：2015-09-17 |
| DOI： |
| 中文关键词: 薄荷脑 气相色谱法 旋光法 含量测定 |
| 英文关键词: menthol gas chromatography polarimetry concentration determination |
| 基金项目:首都卫生发展科研专项项目(首发2011-2008-01) |
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| 摘要点击次数: 3029 |
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| 中文摘要: |
| 目的 分别建立气相色谱法和旋光度测定法测定氨薄荷搽剂中薄荷脑的含量,并将两种方法结果进行统计学分析。 方法 气相色谱法采用DB- WAX (30 m×0.25 mm×0.25 μm)色谱柱,柱温初始温度120℃,保持12 min；进样温度250℃。载气为高纯氦气,汽化温度为250℃,流速为1.0 mL·min-1,按外标法计算结果；旋光度测定法参照2010年版中国药典。结果 气相色谱法测定氨薄荷搽剂中薄荷脑含量检测浓度线性范围为500～1 500 mg·L-1(r=0.999 6),平均回收率为99.13%,RSD=0.34%(n=9)；旋光法测定氨薄荷搽剂中薄荷脑含量检测浓度线性范围为10～30 g·L-1(r=0.999 4),平均回收率为98.65%,RSD=0.85%(n=9)。结论 气相色谱法与旋光度法测定结果没有显著性差异,二者均可用于氨薄荷搽剂中薄荷脑含量的测定,气相色谱法略优于旋光度测定法。 |
| 英文摘要: |
| Objective To establish a method for concentration determination of menthol in ammonia and menthol spiritus.Methods Gas chromatography (GC) and polarimetry were applied for the concentration determination of menthol in ammonia and menthol spiritus,respectively.Results According to GC analysis,the linear range of menthol was 500～1 500 mg·L-1(r=0.999 6),with an average recovery of 99.13%,RSD=0.34%(n=9).In polarimetry analysis,the linear range of menthol was 10～30 g·L-1 (r=0.999 4),with an average recovery of 98.65%,RSD=0.85% (n=9).There were no significant differences between GC and polarimetry in the measurement. Conclusions Polarimetry is simple and accurate,and it is better than GC for the testing of hospital preparations. |
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