| 常文静,蔡佳宇,蔡辉.细胞因子网络介导炎性自身免疫疾病骨丢失的研究进展[J].安徽医药,2016,20(3):409-412. |
| 细胞因子网络介导炎性自身免疫疾病骨丢失的研究进展 |
| Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases |
| 投稿时间：2015-10-13 |
| DOI： |
| 中文关键词: 细胞因子 炎性自身免疫疾病 骨丢失 |
| 英文关键词: cytokine network inflammatory autoimmune diseases bone loss |
| 基金项目: |
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| 中文摘要: |
| 骨重塑是由破骨细胞介导的骨吸收和成骨细胞介导的骨形成维持平衡的持续过程。炎性自身免疫疾病类风湿关节炎、强直性脊柱炎、炎性肠病、系统性红斑狼疮易并发骨丢失和骨折。在慢性炎症状态下,炎性细胞因子网络诱导骨形成和骨丢失解偶联,导致炎性自身免疫疾病患者严重的骨丢失。该文就炎性细胞因子网络在调节炎性自身免疫疾病和骨破坏中的作用作一综述。 |
| 英文摘要: |
| Bone remodeling is a continuous process that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts.Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis,ankylosing spondylitis,inflammatory bowel disease,and systemic lupus erythematosus.The network of inflammatory cytokines produced during chronic inflammation induces an uncoupling of bone formation and resorption,resulting in significant bone loss in patients with inflammatory autoimmune diseases.We review and discuss the involvement of the inflammatory cytokine network in the regulation of inflammatory autoimmune diseases and bone destruction. |
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