| 吴靖,周宏斌,潘松青.莲心碱对氯化锂—匹鲁卡品致癫模型急性期皮层脑电图的影响[J].安徽医药,2016,20(3):449-453. |
| 莲心碱对氯化锂—匹鲁卡品致癫模型急性期皮层脑电图的影响 |
| Effect of liensinine on electrocorticogram in lithium-pilocarpine induced acute epilepsy rats |
| 投稿时间：2015-08-21 |
| DOI： |
| 中文关键词: 癫痫 莲心碱 氯化锂 匹鲁卡品 皮层脑电图 |
| 英文关键词: epilepsy liensinine lithium pilocarpine electrocorticogram 考文献: |
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| 中文摘要: |
| 目的 探讨莲心碱对氯化锂—匹鲁卡品致癫大鼠模型急性期皮层脑电图的影响。方法 32只SD大鼠随机分为生理盐水对照组(A组,10 μg)、低剂量莲心碱组(B组,莲心碱2.5 g·L-1,25 μg)、高剂量莲心碱组(C组,莲心碱5 g·L-1,50 μg)、左乙拉西坦组(D组,100 g·L-1,1 mg),建立氯化锂—匹鲁卡品癫痫大鼠模型后侧脑室注射药物,记录各组大鼠脑电图的改变。结果莲心碱组及左乙拉西坦组与对照组相比大鼠的痫性放电频率减低,快波(β波)比率减少,慢波(δ波)比率增加； 高剂量莲心碱组和左乙拉西坦组相比无统计学差异。结论 莲心碱在氯化锂—匹鲁卡品癫痫大鼠模型急性期具有抗癫痫作用。 |
| 英文摘要: |
| Objective To explore the effect of liensinine on electrocorticogram in lithium-pilocarpine induced acute epilepsy rats.Methods Thirty-two SD rats were randomized into four groups (8 rats in each group):epilepsy model group(group A,10 μg),low dose of liensinine group(group B,2.5 g·L-1,25 μg),high dose of liensinine group(group C,5 g·L-1,50 μg),levetiracetam group (group D,100 g·L-1,1 mg).Electrocorticogram of rats was recorded after lithium-pilocarpine model was induced and the drug was intra-cerebroventricular injected.Results Compared with group A,the epileptic discharge was significantly decreased in groups B,C and D (P<0.05).The proportion of δ slow wave was enhanced,meanwhile β fast wave was decreased in groups B,C and D.And there was no significant difference between high dose of liensinine group and levetiracetam group.Conclusions Liensinine has the role of anti-epilepsy in acute model of epileptic rats induced by lithium-pilocarpine. |
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