| 刘虎军.头孢噻肟钠注射液与4种注射液配伍稳定性考察[J].安徽医药,2016,20(3):458-461. |
| 头孢噻肟钠注射液与4种注射液配伍稳定性考察 |
| Study on compatibility and stability of cefotaxime sodium mixed with 4 kinds of injection |
| 投稿时间：2015-11-17 |
| DOI： |
| 中文关键词: 头孢噻肟钠 氨茶碱 维生素B6 地塞米松磷酸钠 奥硝唑 HPLC 稳定性 |
| 英文关键词: cefotaxime sodium aminophylline vitamin B6 dexamethasone sodium phosphate ornidazole HPLC stability |
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| 中文摘要: |
| 目的 探讨头孢噻肟钠注射液与4种常见注射液的配伍稳定性,以期为头孢噻肟钠注射液的临床合理利用提供一定的参考。方法 建立了头孢噻肟钠高效液相含量测定方法,考察了其与氨茶碱注射液、维生素B6注射液、地塞米松磷酸钠注射液和奥硝唑注射液配伍后含量、外观和溶液pH值的变化。结果 头孢噻肟钠注射液与地塞米松磷酸钠注射液配伍4 h 内外观、pH 值和含量均无明显变化。头孢噻肟钠与氨茶碱注射液配伍后,1 h时配伍溶液出现氨味,4 h时氨味更浓,含量也发生明显变化。头孢噻肟钠与维生素B6注射液配伍pH值虽无明显变化,但含量在2 h内就明显降低。头孢噻肟钠与奥硝唑注射液配伍后,2 h溶液外观发生了变化,在4 h时溶液变成了粉红色,含量明显降低。结论 头孢噻肟钠可与地塞米松磷酸钠注射配伍使用,与维生素B6注射液和氨茶碱注射液不宜配伍使用,若必须与奥硝唑配合,宜在配伍后1 h 内滴注完毕。 |
| 英文摘要: |
| Objective To study the compatibility of cefotaxime sodium mixed in 4 kinds of injection,in order to provide a reference for the clinical rational use of the cefotaxime sodium. Methods The method for cefotaxime sodium HPLC determination was established. The content changes,appearance and pH value of cefotaxime sodium mixed with aminophylline injection,vitamin B6 injection,dexamethasone sodium phosphate injection and ornidazole injection was observed. Results There was no significant change in appearance,pH and content of cefotaxime sodium mixed with vitamin B6 and dexamethasone sodium phosphate in 4 hours. The content had significant change in 4 hours of cefotaxime sodium mixed with aminophylline injection,and 1hour smelled ammonia odor,4 hours become more and more concentrated. The pH value has no significant change,but the content were significantly reduced in 2 hours of Cefotaxime sodium mixed with vitamin B6 injection. The appearance and content had significant change in 4 hours of cefotaxime sodium mixed with ornidazole. Conclusion Cefotaxime sodium can be mixed with dexamethasone sodium phosphate injection,but mixed with vitamin B6 injection and aminophylline injection is not compatible. If it must be matched with ornidazole,should drip within 1 hour. |
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