| 陈家林.血清IL-32与急性心梗患者预后的相关性分析[J].安徽医药,2016,20(3):512-515. |
| 血清IL-32与急性心梗患者预后的相关性分析 |
| Serum levels of interleukin-32 and cardiovascular outcomes in patients with acute myocardial infarction |
| 投稿时间：2015-12-05 |
| DOI： |
| 中文关键词: 急性心肌梗死 白细胞介素-32 炎症 |
| 英文关键词: acute myocardial infarction IL-32 inflammation |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨急性心肌梗死(AMI)患者血清白细胞介素-32 (IL-32)与预后心血管事件风险的关系。方法 研究对象为190例深圳市第二人民医院心内科住院的ST段抬高或非ST段抬高AMI患者。分析血清IL-32与心梗患者2年内复发或死亡风险的相关性。结果 IL-32对已知的心血管危险因素具有显著的影响,如C-反应蛋白(CRP)以及他汀类药物(HR=1.40 (1.03~1.91)；P = 0.03)。IL-32血管内皮细胞黏附分子(VCAM-1)的表达。AMI患者低(低于中位数)IL-32水平和高(高于中位数) VCAM-1水平增加心血管事件发生的风险(HR = 2.22(1.32~3.75)；P = 0.002)。结论 血清低水平IL-32和AMI患者心血管事发生相关。 |
| 英文摘要: |
| Objective To investigate the relationship between serum levels of interleukin-32 (IL-32) and the risk of cardiovascular events in patients with acute myocardial infarction(AMI).Methods We used data from 190 patients enrolled in the prospective,acute ST elevation,or non-ST elevation MI of our department in Shenzhen Second People’s Hospital. Serum levels of IL-32 were associated with the risk of all-cause death and recurrent myocardial infarction(MI) at 2 years,with levels of IL-32 below the median indicative of aworse outcome.Results The impact of IL-32 remained significant after adjustment for known cardiovascular risk factors,C-reactive protein,and treatments including statins:hazard ratio (HR)=1.40 (1.03~1.91);P= 0.03. IL-32 reduced endothelial vascular cell adhesion molecule (VCAM-1) expression. Patients with low (below the median) IL-32 levels and high (above the median) VCAM-1 levels were at particularly increased risk of death and MI:HR = 2.22 (1.32~3.75) compared with the high IL-17/low sVCAM-1 group (P=0.002).Conclusion Low serum levels of IL-32 are associated with a higher risk of major cardiovascular events in patients with AMI. |
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