| 陈肖衣,任卓如,文晓寰,等.右美托咪定对肿瘤化疗患者睡眠、焦虑及恶心呕吐的影响[J].安徽医药,2016,20(3):547-550. |
| 右美托咪定对肿瘤化疗患者睡眠、焦虑及恶心呕吐的影响 |
| Effect of dexmedetomidine on sleep,anxiety,nausea and vomiting in cancer patients undergoing chemotherapy |
| 投稿时间：2015-09-07 |
| DOI： |
| 中文关键词: 右美托咪定 肿瘤 化疗 睡眠 焦虑 恶心 呕吐 |
| 英文关键词: dexmedetomidine cancer chemotherapy sleep anxiety nausea vomiting |
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| 中文摘要: |
| 目的 观察右美托咪定对肿瘤化疗患者睡眠、焦虑及恶心呕吐的影响。方法 选取采取化疗治疗的肿瘤患者120例,采用分层随机分组设计方法,随机数表法分为治疗组(n=60)和对照组(n=60)。治疗组于每晚入睡前持续静脉滴注0.5 μg·kg-1右美托咪定。对照组给予相同剂量和滴注时间的生理盐水。分别利用匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)、中文版恶心呕吐症状评估量表(INVR)评估患者用药前和用药第3天晚上的睡眠、焦虑情况及恶心呕吐症状严重程度。结果 相比治疗前,用药第3天,治疗组患者的匹兹堡睡眠质量指数(PSQI)评分、焦虑自评量表(SAS)分值和患者恶心呕吐症状严重程度均明显减低,差异有统计学意义(t=37.145、7.112、10.407,P均<0.0001)。结论 右美托咪定可以有效改善肿瘤化疗患者的睡眠、焦虑及恶心呕吐症状。 |
| 英文摘要: |
| Objective To observe the effect of dexmedetomidine on sleep,anxiety,nausea and vomiting in cancer patients who received chemotherapy.Methods A hundred and twenty cancer patients suffering from sleep disorders,anxiety symptoms,nausea and vomiting who received chemotherapy from February to May 2015 were selected. Patients were randomized into treatment group (n=60) and control group (n=60). Patients in treatment group were treated with intravenous drip of 0.5 μg·kg-1 dexmedetomidine. Patients in control group were given saline with the same dose and at the same time. Pittsburgh sleep quality index (PSQI),self-rating anxiety scale (SAS),Rhodes index of nausea and vomiting (INVR) were used to assess the sleep quality,anxiety,the number of patients with nausea and vomiting of patients before and the 3rd day after the administration of dexmedetomidine.Results Compared with status before administration of dexmedetomidine,the PSQI scores,SAS scores and the incidence of nausea and vomiting of treatment group were significantly lower in the 3rd day after the administration of dexmedetomidine (t=37.145,7.112,0.407,P=0.000,0.000,0.000,respectively). Conclusions Dexmedetomidine may improve sleep quality and alleviate anxiety,nausea and vomiting symptoms in cancer patients undergoing chemotherapy. |
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