| 卜伟,臧恒昌.肝豆片质量标准改进研究[J].安徽医药,2016,20(5):839-843. |
| 肝豆片质量标准改进研究 |
| Study on the improvement of the quality standard of Gandou TabletsBU Wei1,2,ZANG Heng-chang1 (1.School of Pharmaceutical Sciences Shandong University,Ji′nan,Shandong 250012,China； 2.Hefei Lifeon Pharmaceutical Co.,Ltd.,Hefei 230088,China) Abstract:Objective |
| 投稿时间：2016-02-12 |
| DOI： |
| 中文关键词: 大黄素 色谱法,高压液相 色谱法,薄层 黄连碱 金钱草 质量控制 |
| 英文关键词: Emodin Chromatography,High Pressure Liquid Chromatography,Thin Layer Coptisine Lysimachia Christinae Quality Control |
| 基金项目: |
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| 摘要点击次数: 3741 |
| 全文下载次数: 123 |
| 中文摘要: |
| 目的 增加对肝豆片处方中药材质量控制方法,全面提高肝豆片质量标准,更有效地控制产品的质量。 方法 建立高效液相色谱法对处方中君药大黄进行含量测定,并对处方中臣药黄连、金钱草建立薄层色谱鉴别方法。 结果 黄连鉴别以甲苯-异丙醇-乙酸乙酯-甲醇-水(6∶1.5∶3∶1.5∶0.5)为展开剂,以浓氨水作为饱和溶液,置紫外灯365 nm下检视；金钱草鉴别以甲苯-甲酸乙酯-甲酸(10∶8∶1)为展开剂,以3%三氯化铝乙醇溶液为显色剂,置紫外灯365 nm下检视；大黄含量测定大黄素在8.48～25.44 mg·L-1的浓度范围,峰面积A与浓度C呈现良好的线性关系,相关系数为0.999 4,回收率为95.8%,RSD=0.8%(n=6)。 结论 方法准确、快速、重现性好,质量标准得到改进。 |
| 英文摘要: |
| Objective Increase in hepatic bean prescription medicines quality control methods,quality standards,improving liver beans more effectively control the quality of the products. Method Establish a high performance liquid chromatography determination of liver beans tablets in the content of rhubarb；Using thin-layer chromatography on identification of rhizoma coptidis,lysimachia christinae；Using high-performance liquid chromatographic method for the determination of emodin. Results The identification of the identification of the root of the (6∶1.5∶3∶1.5∶0.5) was used as the solvent,and the concentration of the solution was in the light of the concentration of 365 nm;Hristina loosestrife herb with toluene ethyl formate and formic acid 10∶8∶1 as expansion agent,with 3% solution of aluminium chloride in ethanol as chromogenic agent,placed under ultraviolet light at 365 nm view;Emodin 8.48~25.44 mg·L-1 concentration range,the peak concentration of area a and c presents a good linear relationships,the correlation coefficient is 0.999 4,the returns-ratio is 95.8%,RSD=0.8%(n=6). Conclusion The method is accurate,rapid and with good reproducibility,the quality standards are improved. |
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