| 郭健英,何永成,廖莹,等.泼尼松联合碳酸氢钠与别嘌呤醇治疗IgA肾病合并高尿酸血症的临床效果观察[J].安徽医药,2016,20(5):980-982. |
| 泼尼松联合碳酸氢钠与别嘌呤醇治疗IgA肾病合并高尿酸血症的临床效果观察 |
| Clinic effect of prednisone combined with sodium bicarbonate and allopurinol on the treatment of IgA nephropathy with hyperuricemiaGUO Jian-ying,HE Yong-chen,LIAO Ying,et al (Department of Nephrology,Shenzhen Second People's Hospital,Shenzhen,Guangdong 518035,China)Abstract:Objective |
| 投稿时间：2016-01-05 |
| DOI： |
| 中文关键词: 肾小球肾炎,IGA 高尿酸血症 泼尼松 碳酸氢钠 别嘌呤醇 治疗结果 |
| 英文关键词: Glomerulonephritis,IGA Hyperuricemia Prednisone Sodium Bicarbonate Allopurinol Treatment Outcome |
| 基金项目: |
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| 中文摘要: |
| 目的 观察泼尼松联合碳酸氢钠与别嘌呤醇治疗IgA肾病合并高尿酸血症的临床效果。 方法 IgA肾病合并高尿酸血症的患者90例,随机分为研究组和对照组,各45例。对照组进行泼尼松口服治疗,研究组在此基础上采用碳酸氢钠与别嘌呤醇的联合治疗,所有患者均治疗8w。比较治疗前后两组患者的血肌酐(Scr)、血尿酸(UA)、总胆固醇(TC)和低密度脂蛋白(LDL)、24 h尿蛋白定量和肾小球滤过率(glomerular filtration rate,GFR)等指标的变化。 结果 经治疗,两组患者的Scr、UA、TC、LDL和24 h尿蛋白定量均低于治疗前(P<0.05),GFR高于治疗前(P<0.05)；且治疗后研究组患者的Scr、UA、TC、LDL和24h尿蛋白定量均低于对照组(P<0.05),GFR高于对照组(P<0.05),以上均差异有统计学意义；研究组患者并发症发生率略低于对照组(P>0.05),即研究组的安全性略高于对照组,但是差异无统计学意义。 结论 泼尼松联合碳酸氢钠与别嘌呤醇治疗IgA肾病合并高尿酸血症,能有效降低患者的血肌酐和血尿酸,并能降低患者的血脂水平,有效改善患者的蛋白尿和肾小球滤过情况,临床效果显著,值得推广应用。 |
| 英文摘要: |
| Objective To observe the clinic effect of prednisone combined with sodium bicarbonate and allopurinol on the treatment of IgA nephropathy with hyperuricemia.Methods 90 patients with IgA nephropathy with hyperuricemia were divided them into the research group and the control group,each group has 45 cases:the control group receiving prednisone,and research group receiving prednisone and sodium bicarbonate and allopurinol. The serum creatinine (Scr),blood uric acid (UA),total cholesterol (TC) and low-density lipoprotein (LDL),24 h urine protein excretion and glomerular filtration rate (GFR) of the two groups between and after the treatment were compared.Results After the treatment,Scr,UA,TC,LDL and 24 h urine protein excretion were lower than before the treatment(P<0.05),GFR was higher than before the treatment(P<0.05); and Scr,UA,TC,LDL and 24 h urine protein excretion of the research group were lower than the control group(P<0.05),GFR was higher than the control group (P<0.05),all these differences were statistically significant.Conclusions Prednisone combined with sodium bicarbonate and allopurinol can desearce Scr and UA in patients with IgA nephropathy with hyperuricemia,can reduce blood lipid levels,and improve the situation of proteinuria and glomerular filtration rate,the clinic effect was significant,it was worthy of popularization and application. |
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