| 汪云飞,张帝,周明星,等.盐酸右美托咪定用于老年患者膝关节镜手术腰麻联合硬膜外麻醉的临床观察[J].安徽医药,2016,20(6):1194-1196. |
| 盐酸右美托咪定用于老年患者膝关节镜手术腰麻联合硬膜外麻醉的临床观察 |
| Clinical observation of arthroscopic knee surgery combined with spinal-epidural anesthesia in elderly patients with dexmedetomidine hydrochloride |
| 投稿时间：2015-11-23 |
| DOI： |
| 中文关键词: 麻醉,硬膜外 麻醉,脊椎 右美托咪啶 老年人 |
| 英文关键词: dexmedetomidine hydrochloride combined spinal-epidura anesthesia arthroscopic knee surgery |
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| 中文摘要: |
| 目的 探讨盐酸右美托咪定在膝关节镜手术腰硬联合麻醉中的应用效果及安全性。方法 80例膝关节镜手术患者按随机双盲对照法分为对照组和观察组,每组40例。两组均采取腰硬联合麻醉。对照组在术中静脉泵注生理盐水,观察组术中静脉泵注盐酸右美托咪定。结果 观察组手术开始前5 min(T1)、手术开始时(T2)、手术开始后5 min(T3)、手术开始后30 min(T4)、手术结束时(T5)的收缩压(SBP)、舒张压(DBP)、平均动脉压(MBP)、心率(HR)均显著低于对照组(P<0.05)。观察组术后的皮质醇、去甲肾上腺素(NE)、肾上腺素(E)水平,VAS(疼痛视觉模拟评分法)评分、麻醉不良反应发生率均显著低于对照组,Ramsay评分显著高于对照组,神经阻滞时间及术后恢复时间明显比对照组更长(P<0.05)。结论 在膝关节镜手术腰硬联合麻醉中应用盐酸右美托咪定能有效增强局麻药的镇痛、镇静作用,维持血流动力学稳定,减少麻醉相关并发症的发生。 |
| 英文摘要: |
| Objective To investigate the application effect and security of arthroscopic knee surgery combined with spinal-epidura anesthesia using dexmedetomidine hydrochloride.Methods 80 patients with arthroscopic knee surgery were randomly divided into two groups (n=40),all treated with spinal-epidural anesthesia as well.The control group was given intravenous saline preoperatively,while the research group was given intravenous dexmedetomidine hydrochloride preoperatively.Results SBP,DBP,MBP and HR levels of the research group upon entering operating room(T0),before anesthesia(T1),5 min after anesthesia(T2),beginning of operation(T3),5 min after surgery(T4),and end of surgery(T5) were significantly lower than the control group(P<0.05).Cortisol,NE,E concentrations,VAS scores and anesthesia adverse reaction rates of the research group after surgery were lower than the control group,Ramsay scores were significantly higher,and nerve block time was significantly longer(P<0.05).Conclusions Arthroscopic knee surgery combined with spinal-epidura anesthesia using dexmedetomidine hydrochloride can enhance the local anesthetic analgesia and sedation function effectively,maintain hemodynamic stability,and reduce the incidence of anesthesia-related complications. |
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