| 汪世存,邓克学,潘博,等.18F脱氧葡萄糖PET-CT显像在肺癌分期中的应用价值[J].安徽医药,2016,20(8):1517-1520. |
| 18F脱氧葡萄糖PET-CT显像在肺癌分期中的应用价值 |
| Application value of 18F-FDG PET-CT imaging in lung cancer staging |
| 投稿时间：2016-04-26 |
| DOI： |
| 中文关键词: 肺肿瘤 正电子发射断层扫描及电脑断层扫描 肿瘤分期 癌症早期检测 |
| 英文关键词: Lung neoplasms Positron-emission tomography and computed tomography Neoplasm staging Early detection of cancer |
| 基金项目:安徽省年度重点科研计划(1301043055) 作者简介:汪世存,男,主任医师,硕士生导师,研究方向:PET-CT在肿瘤中的应用,E-mail:wangsc3329@163.com18F脱氧葡萄糖PET-CT显像在肺癌分期中的应用价值汪世存a,邓克学b,潘博a,谢强a,张依凡a (安徽医科大学附属省立医院,a.PET-CT中心,b.CT室,安徽 合肥 230001)18F脱氧葡萄糖PET-CT显像在肺癌分期中的应用价值汪世存,邓克学,潘博,等 Application value of 18F-FDG PET-CT imaging in lung cancer staging WANG Shicun,DENG Kexue,PAN Bo,et al |
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| 中文摘要: |
| 目的 探讨18F脱氧葡萄糖(18F-FDG)PET-CT显像对肺癌TNM分期的诊断价值。方法 回顾性分析行PET-CT全身检查并最终病理确诊的肺癌患者52例病例资料。参照最新TNM分期,判定PET-CT对临床分期的影响,再与病理分期相比较。两种分期进行一致性比较采用Kappa检验,各分期诊断准确率的比较采用χ2检验。M分期经病理、临床治疗及影像随访证实。结果 52例肺癌患者中,PET-CT改变临床分期20 例(20/52,8.4%),其中升高10 例(10/52,9.2%),降低10 例(10/52,19.2%)。行手术治疗的40 例患者中,PET-CT 分期(cTNM) 与病理分期(pTNM)比较,Ⅰ、Ⅱ、Ⅲ及Ⅳ期诊断准确性分别为94.4%(17/18)、25.0%(1/4)、44.4%(4/9)及77.8%(7/9),其中Ⅰ期与Ⅱ、Ⅲ期差异均有统计学意义(P<0.005),cTNM 与pTNM 一致性尚可(Kappa=0.589),总符合率为72.5%。结论 PET-CT对早期肺癌及远处转移具有较高的诊断价值,有助于肺癌的早诊断、早治疗以及判断预后,对制定治疗方案提供一定的临床依据。 |
| 英文摘要: |
| Objective To explore the diagnostic value of 18F-FDG PET-CT imaging in lung cancer staging.Methods We analyzed retrospectively data of 52 patients who underwent PET-CT imaging in Anhui Provincial Hospital from September 2013 to December 2015 and were finally diagnosed lung cancer.According to the latest TNM staging,we estimated the influence of PET-CT on lung cancer clinical staging,and compared it with the pathological staging.In terms of consistency of two kinds of staging,we used Kappa value.When it comes to the comparison of diagnostic accuracy rate in staging,we used Chi-squared texting.M staging was confirmed from pathology,clinical treatment and follow-up imaging.Results Among the 52 cases of patients with lung cancer,PET-CT resulted in changes in 20 cases’ clinical staging (20/52,8.46%),among which 10 cases of staging increased (10/52,9.23%) and 10 cases of staging reduced(10/52,9.23%).Among the 40 cases of surgical treatment,we compared the PET-CT staging (cTNM) with pathological staging (pTNM) and the diagnostic accuracy rates of four stages from Ⅰ to Ⅳ were 94.44% (17/18),25.00% (1/4),44.4% (4/9) and 77.78% (7/9).Among the four stages,there were significant differences between stage Ⅰand stage Ⅱ and Ⅲ (P<0.005),and c-TNM staging and p-TNM staging had an acceptable consistency (Kappa value=0.589).The total coincidence rate was 72.5%.Conclusions 18F-FDG PET-CT has a higher diagnostic value for early lung cancer and distant metastasis,which is helpful in early diagnosis,early treatment and prognosis of lung cancer,and also has a certain application value in clinical treatment. |
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