| 陈峰,蔡莹,何前进.胆囊癌肉瘤的临床特征及其预后影响因素[J].安徽医药,2016,20(8):1524-1526. |
| 胆囊癌肉瘤的临床特征及其预后影响因素 |
| Clinical features and prognostic factors of carcinosacoma of gallbladder |
| 投稿时间：2016-04-21 |
| DOI： |
| 中文关键词: 胆囊肿瘤 疾病特征 预后 Meta分析 |
| 英文关键词: Gallbladder neoplasms Disease attributes Prognosis Meta-analysis |
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| 中文摘要: |
| 目的 总结胆囊癌肉瘤的临床特征及分析影响其预后的临床因素。方法 以计算机自动检索结合人工手动检索的方式对Web of Science、Pubmed、知网、万方和院内图书馆检索2015年12月前发表的有关胆囊癌肉瘤的文献资料分析,由3名研究人员对文献进行评价筛选后提取有用的临床资料以总结胆囊癌肉瘤的临床特征,应用Log-rank检验对患者的生存率及预后因素进行分析。结果 102例患者中男33例,女69例,男∶女=1∶2.09,年龄32～89岁,平均年龄(65.3±9.5)岁,病例分期:Ⅰ期0例,Ⅱ期29例,Ⅲ期18例,Ⅳ期26例,未知的29例,肿瘤大小为1.5～16.8 cm,平均大小为(7.32±2.17)cm；术后生存时间最短者为12 d,最长者为62个月,平均生存时间为(10.1±3.2)个月,其中术后1年、3年和5年生存率分别为23.53%(24/102)、17.65%(18/102)和11.76%(12/102)；应用Log-rank检验对患者生存率进行检验,发现国内患者术后1年、3年和5年生存期显著低于国外组,差异有统计学意义(P<0.05)；Ⅱ期患者1年、3年和5年生存率显著高于Ⅲ期和Ⅳ期患者,差异有统计学意义(P<0.05)。结论 胆囊癌肉瘤具有较高的恶性程度、经治疗后预后较差的临床特征,预后因素与肿瘤所处分期有较大关联,同时人种的不同亦会对患者生存时间有影响。 |
| 英文摘要: |
| Objective To summarize the clinical features and factors influencing the prognosis of carcinosacoma of gallbladder(CSGB).Methods Literature data on CSGB published before December 2015 were retrieved in Web Science,Pubmed,CNKI,Wanfang and HowNet by computer automatic retrieval combined with manual retrieval.The clinical features of CSGB were extracted and evaluated by 3 researchers.The survival rate and prognostic factors of patients were analyzed by Log-rank test.Results Of all 102 cases 33 were males and 69 were females.The ratio of male to female was 1∶2.09.The patients were between 32 and 89 years old,with an average age of(65.3±9.5) years old.There were 0 case of phase I,29 cases of phase II,18 cases of phase III,and 26 cases of phase IV,and 29 cases with unknown phase.Tumor sizes ranged from 1.5 cm to 16.8 cm,the mean size(7.32±2.17) cm.The shortest survival time after the operation was 12 d,while the longest was 62 months,the average survival time being(10.1±3.2) months.The 1-year,3-year and 5-year survival rates were 23.53%(24/102),17.65%(18/102) and 11.76%(12/102),respectively.Log-rank test results showed that the postoperative 1-year,3-year and 5-year survival rates of domestic patients were significantly lower than those of foreign groups,and the difference was statistically significant(P<0.05).The 1-year,3-year and 5-year survival rates of phase II patients were significantly higher than those of phase III and IV patients,and the difference was statistically significant(P<0.05).Conclusions The clinical features of CSGB are high malignancy and poor prognosis after treatment.Prognostic factors are associated with the phases of tumor,and race has an impact on the survival time of the patients. |
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