| 王保存,丁力,张峰.小儿心脏监护病房病原菌分布及超广谱β-内酰胺酶阳性菌的耐药性分析[J].安徽医药,2016,20(8):1530-1532. |
| 小儿心脏监护病房病原菌分布及超广谱β-内酰胺酶阳性菌的耐药性分析 |
| Distribution of pathogenic bacteria and antibiotic resistance of ESBLs bacteria in CICU |
| 投稿时间：2016-04-02 |
| DOI： |
| 中文关键词: 抗药性,细菌 β内酰胺酶类 微生物敏感性试验 重症监护病房,儿科 |
| 英文关键词: Drug resistance,bacterial Beta-lactamases Microbial sensitivity tests Intensive care units,pediatric |
| 基金项目:2013年安徽省卫生厅第二批科研计划项目(13FR024) |
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| 中文摘要: |
| 目的 监测、分析小儿心脏监护病房(CICU)病原菌分布特点及超广谱β-内酰胺酶阳性菌的耐药状况,为指导临床合理用药提供理论依据。 方法 回顾性分析CICU分离的病原菌及耐药性。结果 送检各类标本共计1 192份,检测出病原菌124株(10.4%),主要来源于呼吸道(74株,59.7%),其中革兰阴性菌62株(50.0%)、革兰阳性菌50株(40.3%)、真菌12株(9.7 %)。ESBLs(+)菌共24株(19.4%),均检自肺炎克雷伯菌及大肠埃希菌,对青霉素类、头孢菌素、氨曲南的耐药率高,对氨基糖苷类、喹诺酮类、碳氢霉烯类的耐药率低。结论 CICU病原菌多来源于呼吸道,ESBLs(+)菌的检出率高、耐药严重,应加强监测病原菌分布及耐药性,指导临床合理应用抗菌药物。 |
| 英文摘要: |
| Objective To monitor and analyze the distribution of pathogenic bacteria and antibiotic resistance of ESBLs (+) bacteria in CICU of Anhui Provincial Children’s Hospital,in order to provide the theoretical basis for rational use of antibiotics in clinical practice.Methods A retrospective analysis was made of pathogenic bacteria separated in CICU from January 2011 to December 2015 and of their antibiotic resistance.Results From a total of 1 192 samples,the detected pathogenic bacteria were 124 strains (10.4%),mainly derived from the respiratory tract (74 strains,59.7%).Among them,there were 62 strains (50.0%) of gram-negative bacteria,50 strains (40.3%) of gram positive bacteria and 12 strains (9.7%) of fungus.ESBLs (+) bacteria,a total of 24 strains (19.4%),were both from pneumonia klebsiella bacteria and e.Coli,which were highly resistant to penicillin,cephalosporin and aztreonam,but were lowly resistant to aminoglycoside,quinolone and hydrocarbon alkene.Conclusions Pathogenic bacteria in CICU were mainly derived from respiratory tract.The detection rate of ESBLs (+) bacteria was high and their antibiotic resistance was serious.We should strengthen the monitoring of distribution and antibiotic resistance of pathogenic bacteria,in order to provide guidance for rational use of antibacterial drugs in clinic. |
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