| 邓丹,李远发,陈瑞红,等.不同菌型幽门螺杆菌感染消化性溃疡血清中T细胞亚群的变化及临床意义[J].安徽医药,2016,20(8):1536-1538. |
| 不同菌型幽门螺杆菌感染消化性溃疡血清中T细胞亚群的变化及临床意义 |
| Changes and Clinical significance of Tcell subset in serum of peptic ulcer patients with infection of different types of bacteria Helicobacter Pylori |
| 投稿时间：2015-09-18 |
| DOI： |
| 中文关键词: 消化性溃疡 幽门螺杆菌 T淋巴细胞亚群 因果律 |
| 英文关键词: Peptic ulcer Helicobacter pylori T-lymphocyte subsets Causality |
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| 中文摘要: |
| 目的 检测不同菌型幽门螺杆菌(Hp)感染消化性溃疡(PU)患者血清中T细胞亚群的变化以及白细胞介素-17(IL-17)、转化生长因子-β(TGF-β)的表达。方法 按照随机数字表法选择经胃镜检查确诊的PU患者共88例,同期纳入30例健康体检者作为对照组；检测Hp感染状况并分型,检测所有研究对象外周血T 淋巴细胞亚群活性、IL-17、TGF-β含量。结果 Hp阳性组患者CD4+和IL-17水平明显高于Hp阴性组,而TGF-β水平明显低于Hp阴性组(P＜0.01)；Ⅱ型Hp组患者CD4+和IL-17水平明显低于Ⅰ型Hp组,TGF-β水平明显高于Ⅰ型Hp组(P＜0.01)；在Ⅰ型Hp感染组,十二指肠球部溃疡(DU)患者的CD4+和IL-17表达水平明显高于胃溃疡(GU)患者,而TGF-β水平明显低于GU患者(P<0.01)；在Ⅱ型Hp组,CD4+、IL-17和TGF-β水平在DU与GU间的表达水平差异无统计学意义(P>0.05)。结论 血清CD4+T细胞增高及其细胞因子IL-17和TGF-β的表达异常可能在Hp感染PU中发挥了重要调节作用。 |
| 英文摘要: |
| Objective To investigate changes of Tcell subset in serum of peptic ulcer(PU) patients with infection of different types of bacteria helicobacter pylori(Hp) and expressions of interleukin(IL)-17 and transforming growth factors(TGF)-β.Methods Eighty-eight patients with PU confirmed by gastroscope examination were chosen ifor the study,and at the same time 30 healthy examined people as control group.Types of Hp infection were detected.Peripheral blood Tlymphocyte subsets and NK cells activities were detected by flow cytometer in all cases.Levels of IL-17 and TGF-β were detected by Elisa method.Results CD4+ and IL-17 in Hp positive group were obviously higher,while TGF-β was evidently lower than Hp negative group(P＜0.01).CD4+ and IL-17 in Hp typeⅡgroup were obviously lower,while TGF-β was evidently higher than HpⅠgroup (P＜0.01).In Hp typeⅠgroup,CD4+ and IL-17 of duodenal ulcer(DU) patients were obviously higher,while TGF-β was evidently lower than gastric ulcer(GU) patients(P＜0.05).In Hp typeⅡgroup,CD4+,IL-17 and TGF-β in DU and GU were not significantly different(P＞0.05).Conclusions Increase in serum CD4+ T cell and abnormal expressions of IL-17 and TGF-β may play an important regulating role in PU patients with Hp infection. |
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