| 蒋艳平,王欣,王维春,等.孕11～14周妊娠相关蛋白A联合子宫动脉搏动指数预测早发型子痫前期的研究[J].安徽医药,2016,20(8):1539-1541. |
| 孕11～14周妊娠相关蛋白A联合子宫动脉搏动指数预测早发型子痫前期的研究 |
| Pregnancy-associated protein Acombined with uterine artery pulsatility index in prediction of early-onset pre-eclampsia at 11~14 weeks of gestation |
| 投稿时间：2016-02-18 |
| DOI： |
| 中文关键词: 子痫 妊娠相关血浆蛋白A 搏动血流 妊娠初期 早期诊断 |
| 英文关键词: Eclampsia Pregnancy-associated plasma protein-A Pulsatile flow Pregnancy trimester,first Early diagnosis |
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| 中文摘要: |
| 目的 探讨孕11～14周妊娠相关蛋白A(PAPP-A)联合子宫动脉搏动指数(PI)预测早发型子痫前期的价值。方法 选择单胎妊娠孕妇176例作为观察组,根据妊娠结局分为正常妊娠和子痫前期,对比正常妊娠孕妇和子痫前期孕妇妊娠相关蛋白A及子宫动脉搏动指数。另选择同期孕8～10周单胎妊娠孕妇144例作为对照组,分别计算两组孕妇血清PAPP-A联合子宫动脉PI预测子痫前期时的特异度及敏感度。结果 观察组和对照组的子痫前期发生率分别为5.95%和4.35%,差异无统计学意义(P>0.05)；观察组和对照组中子痫前期孕妇PAPP-A水平均显著低于正常孕妇(P<0.05)；观察组和对照组中子痫前期孕妇子宫动脉(PI)均显著高于正常孕妇(P<0.05)；PAPP-A联合子宫动脉PI检测时,对观察组孕妇的敏感度为85.34%,特异度为81.22%,对照组孕妇的敏感度为80.64%。特异度为68.18%。结论 子痫前期发病前在孕8～10周、孕11～14周时孕妇血清PAPP-A及子宫动脉PI均有显著变化,但血清PAPP-A联合子宫动脉PI预测子痫前期在孕11～14周具有更高的敏感度和特异度,具有更高的预测价值。 |
| 英文摘要: |
| Objective To explore the value of pregnancy-associated protein A (PAPP-A) combined with uterine artery pulsatility index (PI) to predict early-onset preeclampsia at 11~14 weeks of gestation.Methods A total of 176 cases of singleton pregnancy pregnant at 11~14 weeks,selected as the observation group,were assigned into normal pregnancy and preeclampsia according to pregnancy outcome.Pregnancy-associated protein Aand uterine artery pulsation index were compared between normal pregnant women and pregnant women with preeclampsia.At the same time another 144 cases of singleton pregnancy pregnant at 8~10 weeks were selected as control group.Specificity and sensitivity of serum PAPP-A combined with uterine artery PI prediction of preeclampsia were evaluated.Results The incidences of preeclampsia were 5.95% and 4.35% respectively in the observation group and control group,showing no significant difference (P>0.05).The levels of PAPP-A were significantly lower in women with preeclampsia than in normal pregnant women (P<0.05).The uterine artery PI was significantly higher in women with preeclampsia than in normal pregnant women (P<0.05).As for PAPP-A combined with uterine artery PI test,the sensitivities and specificities were 85.34% vs 80.64%,and 81.22% vs 68.18% in observation and control group.Conclusions Serum PAPP-A and uterine artery PI both changed obviously in women pregnant at 8-10 weeks and 11-14 weeks before the onset of preeclampsia,however the combination of serum PAPP-A and uterine artery PI in prediction of preeclampsia at 11-14 weeks of gestation is more sensitive and specific,which has higher predictive value. |
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