| 王啟燕,李杰.乌体林斯对支气管哮喘患儿机体免疫指标的影响及远期效果观察[J].安徽医药,2016,20(8):1597-1599. |
| 乌体林斯对支气管哮喘患儿机体免疫指标的影响及远期效果观察 |
| Effect and observation of long-term effects of Mycobacterium Phlei F.U.36 Injection on body′s immune indexes in children with bronchial asthma |
| 投稿时间：2016-02-22 |
| DOI： |
| 中文关键词: 哮喘 草分枝杆菌 T淋巴细胞亚群 免疫蛋白质类 白细胞介素4 |
| 英文关键词: Asthma Mycobacterium phlei T-lymphocyte subsets Immunoproteins Interleukin-4 |
| 基金项目: |
|
| 摘要点击次数: 3618 |
| 全文下载次数: 146 |
| 中文摘要: |
| 目的 探讨乌体林斯治疗支气管哮喘远期效果及对机体免疫、变态反应指标的影响,以期为乌体林斯治疗支气管哮喘近、远期疗效提供可靠依据。方法 选取支气管哮喘患儿104例,随机单盲取法分为观察组与对照组各52例,对照组给予常规治疗,观察组在对照组基础上给予乌体林斯治疗,观察两组患者治疗前后免疫指标(T淋巴细胞及亚群:CD3+、CD4+、CD8+、CD4+/CD8+；免疫蛋白:IgA、IgG、IgM、IgE)、变态反应相关指标嗜酸性粒细胞(EOS)、嗜酸细胞阳离子蛋白(ECP)及白细胞介素-4(IL-4)变化。治疗后随访1年,观察两组患儿复发情况。结果 两组治疗前各项免疫指标及变态反应相关指标比较,差异无统计学意义,观察组治疗后IgG、IgM、CD3+、CD8+、CD4+/CD8+均高于同组治疗前及对照组同期(P<0.05),IgE低于同组治疗前及对照组同期(P<0.05),各项变态反应相关指标均低于同组治疗前及对照组治疗后(P<0.05),观察组治疗8周总有效51例,总有效率98.1%,高于对照组的40例(76.9%),差异有统计学意义(P<0.05),随访1年观察组2例患儿复发,对照组15例复发,两组复发率比较,差异有统计学意义(P<0.05)。结论 支气管哮喘患儿给予乌体林斯,可提高患儿免疫功能,改善变态反应,提高治疗效果,降低远期复发率,值得临床推广。 |
| 英文摘要: |
| Objective To investigate the long-term effects of Mycobacterium Phlei F.U.36 Injection in the treatment of patients with bronchial asthma and its effect on the immune and allergy indexes,so as to provide reliable reference for recent and long-term efficacy of Mycobacterium Phlei F.U.36 Injection in the treatment of bronchial asthma.Methods Totally 104 cases of children with bronchial asthma were randomized into two groups:the observation group (n=52) and the control group (n=52).The control group received conventional treatment,while the observation group took Mycobacterium Phlei F.U.36 Injection besides conventional treatment.Changes in the immune indexes (T lymphocytes and subsets:CD3+,CD4+,CD8+,CD4+/CD8+;immune proteins:IgA,IgG,IgM,IgE),allergy-related indicators of eosinophils (EOS),eosinophil cationic protein (ECP) and interleukin-4 (IL-4) of the two groups before and after treatment were observed.Follow-up was conducted after treatment for a year,and the recurrence rates of the two groups were observed.Results There were no significant differences in immune indexes and allergy-related indicators between the two groups before treatment.The IgG,IgM,CD3+,CD8+,CD4+/CD8+ in the observation group after treatment were higher than before treatment and the control group during the same period (P<0.05).IgE and the allergy-related indicators in the observation group after treatment were lower than before treatment and the control group during the same period (both P<0.05).The therapeutic effect (51 cases,98.1%) in the observation group 8 weeks after treatment was significantly higher than that in the control group (40 cases,76.9%;P<0.05).There was significant difference in recurrence rate between the observation group and the control group during 1 year of follow-up (2 cases vs 15 cases;P＜0.05).Conclusions Mycobacterium Phlei F.U.36 Injection in the treatment of patients with bronchial asthma can improve immune function,alleviate allergies,promote therapeutic effect and reduce long-term recurrence rate,which is worthy of promotion in clinic. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
