| 万丽娟,陈明卫.胰高血糖素样肽-1对糖尿病周围神经病变的影响[J].安徽医药,2016,20(9):1617-1620. |
| 胰高血糖素样肽-1对糖尿病周围神经病变的影响 |
| Effect of glucagon-like peptide-1 on diabetic peripheral neuropathyWAN Lijuan,CHEN Mingwei (Department of Endocrinology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China)Abstract: |
| 投稿时间：2016-03-07 |
| DOI： |
| 中文关键词: 糖尿病神经病变 胰高血糖素样肽-1 |
| 英文关键词: |
| 基金项目: |
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| 摘要点击次数: 2723 |
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| 中文摘要: |
| 胰高血糖素样肽-1(GLP-1)是肠道因进食而分泌的一类促胰岛素分泌肽,主要通过作用于GLP-1受体,激活多种信号通路而对神经系统发挥影响,主要包括加快神经传导速度,增加神经轴突的数量,为神经细胞直接提供营养因子,抑制神经细胞凋亡,拮抗氧化应激等作用。GLP-1及其受体激动剂可通过多种不同的途径改善糖尿病周围神经病变的症状,为糖尿病周围神经病变的治疗提供新的方法。 |
| 英文摘要: |
| Glucagon-like peptide-1 is a kind of insulin secreting peptide secreted by intestine Lcells during eating,which plays a role for the nervous system mainly acting on GLP-1 receptor to activate multiple signaling pathways.It mainly includes such roles as speeding up the nerve conduction velocity,increasing the number of nerve axons,providing nutritional factor directly to neurons,inhibiting neuron apoptosis,and resisting oxidative stress.Glucose-like peptide-1 and glucagon-like peptide-1 receptor agonist can improve the symptoms of diabetic peripheral neuropathy through several different ways,which provides a new method for the therapy of diabetic peripheral neuropathy. |
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