| 王峰.四逆汤口服联合尿激酶溶栓治疗对改善急性ST段抬高型心肌梗死患者缺血再灌注损伤的效果观察[J].安徽医药,2016,20(9):1735-1738. |
| 四逆汤口服联合尿激酶溶栓治疗对改善急性ST段抬高型心肌梗死患者缺血再灌注损伤的效果观察 |
| Effect of Si ni tang combined with urokinase on the treatment of acute ST-segment elevation myocardial infarction WANG Feng (Yucheng Chinese Medicine Hospital Emergency Departments,Dezhou,Shandong 251200,China) Abstract:Objective |
| 投稿时间：2016-06-01 |
| DOI： |
| 中文关键词: 心肌梗死 再灌注损伤 尿激酶型纤溶酶原激活物 血栓溶解疗法 四逆汤 治疗结果 |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 3129 |
| 全文下载次数: 70 |
| 中文摘要: |
| 目的 观察四逆汤口服联合尿激酶溶栓治疗对改善急性ST段抬高型心肌梗死患者缺血再灌注损伤的效果。 方法 急性ST段抬高型心肌梗死患者83例,随机双盲法将所有患者分为观察组42例和对照组41例。对照组患者给予尿激酶溶栓治疗,观察组给予口服四逆汤和尿激酶溶栓联合治疗。分析治疗前后两组患者心肌损伤标记物血浆心肌肌钙蛋白T(cTnT)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)和超氧化物歧化酶(SOD)的水平、患者ST段抬高总和回落百分比、治疗后总有效率、血管再通率和治疗后不良事件发生情况。 结果(1)治疗后观察组cTnT和LDH水平分别为[(0.81±0.09)μg·L-1、(262.54±34.16)U·L-1],均优于对照组[(1.21±0.18)μg·L-1、(331.28±45.18)U·L-1],且均差异有统计学意义(P<0.05)。(2)治疗后观察组CK-MB和SOD水平分别为(47.14±5.31)、(171.83±25.09)U·L-1,均优于对照组(68.57±6.08)、(135.25±21.74)U·L-1,且均差异有统计学意义(P<0.05)。(3)治疗后观察组ST段抬高总和回落百分比为(87.79±3.10)%,高于对照组(71.42±2.94)%,且差异有统计学意义(P<0.05)。(4)治疗后观察组总有效率为80.95%,显著高于对照组58.54%,且差异有统计学意义(P<0.05)；治疗后观察组血管再通率为71.43%,对照组65.85%,差异无统计学意义(P>0.05)。(5)治疗后观察组患者发生的不良事件率为26.19%,显著低于对照组56.10%,且差异有统计学意义(P<0.05)。 结论 四逆汤口服和尿激酶溶栓联合用药对急性ST段抬高型心肌梗死患者的缺血再灌注损伤心肌起到良好的保护作用,降低治疗后的不良事件发生,提高整体治疗效果,联合用药效果优于单独用药,且安全性较高。 |
| 英文摘要: |
| Objective To observe the effect of Si ni tang combined with urokinase on the treatment of acute ST-segment elevation myocardial infarction. Methods 83 patients with acute ST segment elevation myocardial infarction were randomized double-blindly divided into observation group of 42 and control group of 41.The control group were treated with thrombolytic therapy,observation group was given oral Sini soup and urokinase combination therapy.Two groups of patients before and after treatment of myocardial injury markers in plasma cardiac troponin T (cTnT),lactate dehydrogenase (LDH),creatine kinase (CK-MB) and superoxide dismutase (SOD) levels the sum of the percentage decline in patients with ST-segment elevation,the total efficiency of the treatment,adverse events after revascularization rates and treatment. Results After treatment,the observation group cTnT and LDH levels were [(0.81±0.09)μg·L-1,(262.54±34.16)U·L-1],than the control group [(1.21±0.18)μg·L-1,(331.28±45.18)U·L-1],and the differences were statistically significant (P<0.05).Treatment observation group CK-MB and SOD levels were (47.14±5.31),(171.83±25.09) U·L-1,than the control group (68.57±6.08),(135.25±21.74) U·L-1,and the difference was significant (P<0.05).After treatment observation group ST segment elevation lower percentage of the sum of (87.79±3.10)%,the control group (71.42±2.94)%,and the difference was significant (P<0.05).After treatment,the observation group total effective rate was 80.95%,significantly higher than 58.54%,and the difference was significant (P<0.05);after treatment,the observation group recanalization rate was 71.43%,higher than 65.85 percent,but the difference was not significant (P>0.05).Adverse events observed in patients after treatment occurrence rate of 26.19%,significantly lower than the control group,56.10%,and the difference was significant (P<0.05). Conclusion Sini decoction oral and urokinase combination therapy for acute ST segment elevation myocardial infarction in patients with myocardial ischemia-reperfusion injury play a good protective effect,reducing the occurrence of adverse events after treatment,to improve the overall treatment effect,combination therapy is better than monotherapy,and higher security. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
