| 胡英芳,王灿敏,宋云峰,等.Toll样受体4基因Asp299Gly多态性与脑膜炎球菌病易感性的Meta分析[J].安徽医药,2016,20(10):1929-1932. |
| Toll样受体4基因Asp299Gly多态性与脑膜炎球菌病易感性的Meta分析 |
| A Meta-analysis of TLR4 Asp299Gly polymorphism contributing to meningococcal disease |
| 投稿时间：2016-06-29 |
| DOI： |
| 中文关键词: TLR4基因Asp299Gly多态性 多态性 单核苷酸 脑膜炎球菌病 Meta分析 |
| 英文关键词: TLR4 Asp299Gly Polymorphism Single nucleotide Meningococcal disease Meta-analysis |
| 基金项目:广东省医学科学技术研究基金(A2016568)Toll样受体4基因Asp299Gly多态性与脑膜炎球菌病易感性的Meta分析胡英芳1,王灿敏1,宋云峰1,王朦夏1,魏宜1,李泽华2a,李夏西2b (1.广东省第二人民医院重症医学科,广东 广州 510310；2.南方医科大学深圳医院a.整形外科,b.肿瘤科,广东 深圳 518000)Toll样受体4基因Asp299Gly多态性与脑膜炎球菌病易感性的Meta分析 胡英芳,王灿敏,宋云峰,等 |
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| 中文摘要: |
| 目的 探讨Toll样受体4(TLR4)基因Asp299Gly多态性与脑膜炎球菌病易感性的关系。方法 检索Pubmed,Cohrance,Embase,CNKI,维普,万方等数据平台从建库截止到2015 年12 月31日的文献,搜寻符合纳入和排除条件的随机对照研究,RevMan5.0.0软件进行Meta分析。结果 共纳入4 篇文献,样本总量3 707例,其中研究组1 681例,对照组2 026例。Meta分析未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关(等位基因A vs G∶OR=1.01,95% CI=0.84~1.23,P=0.89；基因型AA/AG vs GG∶OR=1.05,95% CI=0.55~2.02,P=0.87；基因型AA vs AG/GG∶OR=1.01,95% CI=0.82~1.24,P=0.95)。结论 未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关。 |
| 英文摘要: |
| Objective To investigate the association between TLR4 Asp299Gly polymorphism and meningococcal disease.Methods Pubmed,Embase,Cohrance,CNKI,VIP,Wanfang Database were searched to get related literature of clinical controlled trials.Meta-analysis was conducted by RevMan 5.0.0 software.Results Four case-control studies with 1681 patients and 2026 healthy controls were included.Meta-analysis showed that there was no significant correlation between TLR4 Asp299Gly polymorphism and meningococcal disease (allele Avs G∶OR=1.01,5% CI=0.84~1.23,P=0.89;AA/AG vs GG∶OR=1.05,5% CI=0.55~2.02,P=0.87;AA vs AG/GG∶OR=1.01,5% CI=0.82~1.24,P=0.95).Conclusion No significant correlation between TLR4 Asp299Gly polymorphism and meningococcal disease was found in the meta-analysis. |
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