| 王晓亮,赵英水.人附睾分泌蛋白4在各分期慢性肾脏疾病患者血清中变化及临床价值[J].安徽医药,2016,20(11):2078. |
| 人附睾分泌蛋白4在各分期慢性肾脏疾病患者血清中变化及临床价值 |
| Changes of serum HE3 levels in various stages of chronic kidney disease and its clinical significance |
| 投稿时间：2016-06-20 |
| DOI： |
| 中文关键词: 慢性肾脏疾病 人附睾分泌蛋白4 分期 肾功能不全 |
| 英文关键词: Chronic kidney disease HE4 Staging Renal dysfunction |
| 基金项目:陕西省科学技术研究发展计划项目(2011K12-69)人附睾分泌蛋白4在各分期慢性肾脏疾病患者血清中变化及临床价值王晓亮1,赵英水2 (1.榆林市第一医院检验科,陕西 榆林 719000；2.西北大学,陕西 西安 710000)人附睾分泌蛋白4在各分期慢性肾脏疾病患者血清中变化及临床价值 王晓亮,赵英水 |
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| 中文摘要: |
| 目的 探讨人附睾分泌蛋白4(HE4)在各分期慢性肾脏疾病患者血清中变化及临床价值。方法 选取慢性肾脏疾病(CKD)患者136例,根据肾小球滤过率(eGRF)值将患者分为CKD1期(n=41)、CKD2期(n=33)、CKD3期(n=17)、CKD4期(n=21)和CKD5期(n=24),将eGRF<60 mL·min-1作为肾功能不全的诊断标准,同期,选取健康者40例作为对照组,检测血尿素氮(BUN)、肌酐(Scr)、尿酸(UA)和胱蛋白酶抑制剂C(CysC)水平,利用酶联免疫吸附试验(ELISA法)对血清中HE4水平进行检测,利用受试者工作特征曲线(ROC曲线)对血清中不同指标在预测肾功能不全中的价值进行分析。结果 与对照组相比,CKD患者血清HE4、BUN、Scr、UA和CysC水平均升高,CKD患者中,CKD3期、CKD4期和CKD5期患者血清HE4、BUN、Scr、UA和CysC水平均高于CKD1期和CKD2期患者,且CKD2期患者血清HE4高于CKD1期,差异均有统计学意义(P<0.05)；Pearson相关分析显示,CKD患者血清中HE4水平与BUN、Scr和CysC均呈正相关(r=0.295、0.342和0.416,P<0.05),Spearman相关分析显示,CKD患者血清中HE4水平与CKD分期呈正相关(rs=0.497,P<0.05)；ROC曲线分析显示,CKD患者血清中HE4、BUN、Scr、UA和CysC均对肾功能不全具有预测价值,且HE4在预测肾功能不全时,曲线下面积、灵敏度和特异度均优于BUN、Scr、UA和CysC。结论 HE4在CKD患者血清中出现升高,且随患者分期而逐渐增加,可作为早期发现肾功能不全的辅助诊断指标。 |
| 英文摘要: |
| Objective To investigate the changes of serum human epididymis protein 4(HE3)levels in various stages of chronic kidney disease and its clinical significance.Methods Totally136 cases of patients with chronic kidney disease(CKD)were selected.According to estimated glomerular filtration rate(eGRF),the patients were assigned stage 1 group(n=41),stage 2 group(n=33),stage 3 group(n=17),stage 4 group(n=21)and stage 5 group(n=24).The eGFR<60 mL·min-1was used as the diagnostic criteria for renal dysfunction.In the same period,40 healthy subjects were selected as control group.The blood urea nitrogen(BUN),serum creatinine(Scr),uric acid(UA)and cystatin C(CysC)were detected.The serum level of HE4 was detected by using enzyme-linked immunosorbent assay(ELISA method).The values of different indicators in predicting renal dysfunction were analyzed by using receiver operating characteristic curve(ROC curve).Results Compared with the control group,the serum levels of HE4,BUN,Scr,UA and CysC in patients with CKD were increased.Among the patients with CKD,the serum levels of HE4,BUN,Scr,UA and CysC in stage 3 group,stage 4 group and stage 5 group were higher than stage 1 group and stage 2 group,and the serum level of HE4 in stage 2 group was higher than stage 1 group.The differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum level of HE4 in patients with CKD was positively correlated with BUN,Scr and CysC(r=0.295,0.342 and 0.416,respectively;P<0.05).Spearman correlation analysis showed that the serum level of HE4 in patients with CKD was positively correlated with CKD staging(rs=0.497,P<0.05).ROC curve analysis showed that the serum levels of HE4,BUN,Scr,UA and CysC in patients with CKD all had values in predicting renal dysfunction,and as for HE4,the area under the curve,sensitivity and specificity were better than BUN,Scr,UA and CysC.Conclusions The serum level of HE4 was elevated in patients with CKD,and was gradually increased with the staging of patients,which could be used as adjuvant diagnostic marker for early detection of renal dysfunction. |
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