| 屈小洁.米索前列醇联合子宫动脉下行支结扎治疗宫缩乏力性产后出血的效果观察[J].安徽医药,2016,20(11):2143-2146. |
| 米索前列醇联合子宫动脉下行支结扎治疗宫缩乏力性产后出血的效果观察 |
| Clinical observation of uterine artery ligation combined with misoprostol in treatment of postpartum hemorrhage caused by uterine inertia |
| 投稿时间：2016-08-15 |
| DOI： |
| 中文关键词: 米索前列醇 子宫动脉下行支结扎 宫缩乏力性产后出血 前列腺素 肾素-血管紧张素-醛固酮系统 |
| 英文关键词: Misoprostol Uterine artery ligation Postpartum hemorrhage caused by uterine inertia Prostaglandin Renin angiotensin aldosterone system |
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| 中文摘要: |
| 目的 探讨米索前列醇联合子宫动脉下行支结扎治疗宫缩乏力性产后出血的疗效及产后恢复情况。方法 选取124例宫缩乏力性产后出血患者,随机数字表法分为对照组、米索前列醇治疗组(A组)、子宫动脉下行支结扎治疗组(B组)、子宫动脉下行支结扎联合米索前列醇治疗组(C组)；观察术后2 h、术后24 h 的出血量、产后恢复情况,检测血常规、血生化指标的变化。结果 A、B、C组24 h出血量、持续出血(2~24 h)量和产褥病率均低于对照组；产后24 h时,A、B、C组的红细胞计数(RBC)、血红蛋白测定(HB)、红细胞比容(HCT)、前列腺素E2(PGE2)、PGF2α含量均高于对照组,血清中抗利尿激素、肾素、血管紧张素II、醛固酮、6-keto-PGF1α的含量均低于对照组；C组的RBC、HB、HTC、PGE2、PGF2α含量均高于A、B组,血清中抗利尿激素、肾素、血管紧张素II、醛固酮、6-keto-PGF1α的含量均低于A、B组；三组间恶露时间和产后月经量,产后月经周期的差异无统计学意义(P＞0.05)。结论 米索前列醇联合子宫动脉下行支结扎能够更为有效地减少宫缩乏力性产后出血患者的出血量,同时调节前列腺素含量、抑制肾素-血管紧张素-醛固酮系统的激活。 |
| 英文摘要: |
| Objective To study the curative effect and postpartum recovery of uterine artery ligation combined with misoprostol in treatment of postpartum hemorrhage caused by uterine inertia.Methods A hundred and twenty-four cases of patients with postpartum hemorrhage caused by uterine inertia were randomized into control group,misoprostol treatment group(group A),uterine artery ligation group(group B)and uterine artery ligation combined with misoprostol treatment group(group C).Blood loss 2 h and 24 h after surgery and postpartum recovery of patients in two groups were observed,and the changes in blood routine and blood biochemical indexes were determined.Results 24 h blood loss,(2~24 h)continued bleeding volume and puerperal morbidity of group A,B,and Cwere lower than control group;24h after labor,RBC,HB,HTC,PGE2,PGF2α of group A,B,and Cwere significantly higher than control group,while serum vasopressin,renin,angiotensin II,aldosterone,6-keto-PGF1α were significantly lower than control group.RBC,HB,HTC,PGE2,PGF2α of group Cwere significantly higher than group Aand B,while serum vasopressin,renin,angiotensin II,aldosterone,6-keto-PGF1α of group Cwere significantly lower than group Aand B.Menstruation and postpartum lochia time,postpartum menstrual cycle among the three groups were not significantly different(P>0.05).Conclusions Misoprostol combined with uterine artery ligation can more effectively reduce blood loss of patients with postpartum hemorrhage caused by uterine inertia,meanwhile regulate prostaglandin content,and inhibit the activation of renin-angiotensin-aldosterone system. |
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