| 毛古燧,黄传兵,汪元,等.尿酸转运蛋白在原发性痛风中的研究进展[J].安徽医药,2017,21(1):7-10. |
| 尿酸转运蛋白在原发性痛风中的研究进展 |
| Research progress of urate transporter proteins in primary gout |
| 投稿时间：2016-07-13 |
| DOI： |
| 中文关键词: 尿酸转运蛋白 原发性痛风 研究进展 |
| 英文关键词: Urate transporter protein Primary gout Research progress |
| 基金项目:国家中医药管理局重点学科资助项目(2011bbxk003) |
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| 中文摘要: |
| 痛风是长期嘌呤代谢紊乱所导致的一种炎症性关节炎,具有一定的基因遗传性。基因突变所引起的功能缺失可导致原发性高尿酸血症与痛风,肾脏尿酸盐转运系统是原发性痛风相关基因研究的重点,维持尿酸盐的吸收和分泌平衡对血清尿酸水平的稳定起着决定性的的调节作用。该文对目前已发现的与原发性痛风发生、发展相关的尿酸转运蛋白作简要概述,以供临床合理诊治原发性痛风提供参考。 |
| 英文摘要: |
| Gout,a hereditary disease associated with genes,is an inflammatory arthritis caused by long-term abnormal metabolism of purine.Functional deficiency caused by gene mutation may lead to primary hyperuricemia and gout.The transport system of urate in kidney is a research emphasis about genes associated with primary gout.The balance of absorption and secretion of urate in kidney is a major factor determining the serum concentration of uric acid.This article briefly outlines the urate transporter proteins related to the occurrence and development of primary gout.Research offers the reference for further rational diagnosis and treatment of primary gout. |
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