| 杨欢,鲍静影,蒋苗苗,等.阿片受体激动剂的镇痛作用及其靶点通路研究进展[J].安徽医药,2017,21(2):211-215. |
| 阿片受体激动剂的镇痛作用及其靶点通路研究进展 |
| Research of analgesic effect and signaling pathways for opioid receptor agonists |
| 投稿时间：2016-07-15 |
| DOI： |
| 中文关键词: 疼痛 阿片类受体 激动剂 信号通路 |
| 英文关键词: Pain Opioid receptor Agonist Signaling pathway |
| 基金项目:安徽省自然科学基金项目(1608085QH211) |
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| 摘要点击次数: 2203 |
| 全文下载次数: 2232 |
| 中文摘要: |
| 疼痛是一种复杂的生理现象,目前主要运用药物进行镇痛。阿片类受体激动剂类镇痛药受到了越来越多的关注,阿片受体及其与药物的作用机制研究取得了较大发展,近年来逐渐被用于临床治疗疼痛,但由于没有研究可以对其镇痛以及成瘾的机制进行明确地阐释,因此阿片受体激动剂在临床上没有得到广泛应用。探讨阿片类受体的结构特点和作用机制,并在此基础上开发结构全新或新作用机制的镇痛药物,是推动阿片类受体激动剂在临床上用于镇痛治疗的前提。综述阿片类受体激动剂在镇痛方面的应用及其信号通路,可以为今后高选择性镇痛药的研发及临床治疗提供思路。 |
| 英文摘要: |
| Pain is a complex physiological phenomenon.Most of drugs used in the treatment of pain are analgesics.Analgesic effect of opioid receptor agonist represents an important emerging area of interest,and the study of opioid receptors and their interaction with drugs been greatly developed.Opioid receptor agonists have been used in the clinical treatment of pain.However,the obscure of the mechanism underlying the analgesic effect and addiction limits the clinical usage of the opioid receptor agonists.Exploring the structural characteristics and mechanism of opioid receptors,and developing novel structure of analgesic drugs are the prerequisite for the development of opioid receptor agonists in the treatment of pain.Reviewing the effect and the signal pathway of the opioid receptor agonists for analgesia could provide helpful data for the further development in analgesic drug and clinical treatment. |
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