| 陈诚,肖政祥,张丹,等.早产儿解脲脲原体菌血症和白细胞介素-6、白细胞介素-8浓度测定的临床意义[J].安徽医药,2017,21(2):306-308. |
| 早产儿解脲脲原体菌血症和白细胞介素-6、白细胞介素-8浓度测定的临床意义 |
| Clinical significance of the measurements of plasma Uu-DNA copies and IL-6,IL-8 concentration in very premature infants |
| 投稿时间：2016-07-11 |
| DOI： |
| 中文关键词: 解脲脲原体菌血症 白细胞介素-6 白细胞介素-8 血浆 极不成熟儿 |
| 英文关键词: Uu-DNA copies IL-6 levels IL-8 levels Plasma Very premature infants |
| 基金项目:深圳市科技研发资金项目(JCYJ20140415133340848)(SIRS)、支气管肺发育不良(BPD)及脑室内出血(IVH)发生率也明显增高[1-2],但国内未见类似相关性研究的报道。本研究报道75例极不成熟婴儿(胎龄＜32周)血浆Uu菌血症(Uu-DNA阳性)拷贝数和IL-6、IL-8浓度与宫内感染性肺炎、BPD、IVH的相关性,探讨Uu在新生儿临床中的意义,现报道如下。 |
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| 中文摘要: |
| 目的 探讨早产儿血浆解脲脲原体菌血症(Uu-DNA阳性)和白细胞介素-6(IL-6)、白细胞介素-8(IL-8)浓度检测的意义。 方法 对75例胎龄＜32周的极不成熟婴儿于生后不同时间分别采静脉血标本,测定血浆Uu-DNA拷贝数和IL-6、IL-8浓度,记录婴儿住院期间的病情变化。 结果 9例(12%)在出生后1 h内血浆标本中检出Uu-DNA,其中7例Uu-DNA出现在宫内感染性肺炎患儿,以后时间所采标本均未检出Uu-DNA；Uu-DNA阳性患儿出生后1 h内血浆IL-6、IL-8浓度明显增高(P＜0.05)；Uu-DNA阳性患儿支气管肺发育不良发生率显著增高。 结论 极不成熟儿Uu-DNA阳性率占12%；Uu-DNA阳性患儿血浆炎性因子明显增高,支气管肺发育不良(BPD)发生也明显升高。 |
| 英文摘要: |
| Objective To explore clinical significance of the measurements of plasma Ureaplasma urealyticum (Uu)-DNA copies and interleukin(IL-6),IL-8 concentration in very premature infants. Methods Venous blood samples were collected during 1h,3d,7d,14d,21d of life from 75 consecutive singleton deliveries of very premature infants (gestational age＜32 weeks),and plasma Uu-DNA copies and IL-6,IL-8 concentration were measured. Results 9 cases were detected plasma Uu-DNA copies from samples within 1 h,prevalence of Uu bacteremia was 12%(9/75).Uu-DNA copies in all cases were undetected.Plasma IL-6 and IL-8 concentration of Uu bacteremic infants were significant higher compared with others from samples within 1 h(P＜0.05).The incidence of bronchopulmonary dysplasia (BPD) were significant higher in Uu bacteremic infants. Conclusions Prevalence of Uu bacteremia in very premature infants was 12 %.Uu bacteremic infants had significant higher plasma proinflammatory cytokines level and the higher incidence of BPD(p＜0.05). |
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