| 吴海波,李恒,钟文.WT-1在中枢神经系统孤立性纤维性肿瘤/血管周细胞瘤中表达及临床病理学研究[J].安徽医药,2017,21(8):1402-1405. |
| WT-1在中枢神经系统孤立性纤维性肿瘤/血管周细胞瘤中表达及临床病理学研究 |
| Clinicopathological analysis of WT-1 expression in solitary fibrous tumor/haemangiopericytoma of central nervous system |
| 投稿时间：2017-01-05 |
| DOI： |
| 中文关键词: WT-1 中枢神经系统 孤立性纤维性肿瘤 血管周细胞瘤 |
| 英文关键词: WT-1 Central nervous system Solitary fibrous tumor Haemangiopericytoma 之,WT-1在中枢神经系统SFT/HPC的小血管呈强弱不等表达或不表达,在毛细血管呈弥漫性强阳性表达,而在脑膜瘤的表达与其内血管的大小和肿瘤的类型及分级均无明显关联性(r=0.027 27,P=0.757 2)。因此,WT-1免疫组化染色可作为区别两者的标记物,也可作为抗中枢神经系统SFT/HPC血管生成治疗的潜在靶点。 参考文献: |
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| 中文摘要: |
| 目的 探讨WT-1在中枢神经系统孤立性纤维性肿瘤/血管周细胞瘤(SFT/HPC)中的表达情况及临床病理学意义。方法 回顾性分析36例中枢神经系统SFT/HPC的WT-1免疫组织化学染色情况,以29例脑膜瘤作为对照。结果 SFT/HPC以瘤细胞围绕血管形成血管外皮瘤样结构为特点,肿瘤小血管呈WT-1强弱不等的阳性表达或不表达,而毛细血管呈弥漫性强阳性表达。在脑膜瘤中,WT-1表达与肿瘤血管的大小和肿瘤的类型及分级无明显关联性(r=0.027 27,P=0.757 2)。结论 WT-1可作为SFT/HPC区别脑膜瘤的标记物,将来也可作为抗SFT/HPC血管生成治疗的潜在靶点。 |
| 英文摘要: |
| Objective To investigate the expression of WT-1 in solitary fibrous tumor/haemangiopericytoma(SFT/HPC) of central nervous system and its clinicopathological significance. Methods Retrospective analysis was conducted of the immunohistochemical staining of WT-1 in 36 cases of SFT/HPC of central nervous system,29 cases of meningioma were used as control. Results SFT/HPC was characterized by the formation of haemangiopericytoma-like structure.The small vessels of the tumors exhibited positive expression or no expression of WT-1,while the capillaries diffusely and strongly expressed WT-1 protein.The expression of WT-1 was not correlated with the size of tumor vessels,the types and the grades of meningioma(r=0.027 27,P=0.757 2). Conclusion WT-1 can be used as a marker to differentiate meningiomas from SFT/HPC,and may also be a potential target for anti-angiogenic treatment in SFT/HPC. |
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